Miyashita T, Ojima A, Tuji T, Tajima T, Watanabe K
Acta Pathol Jpn. 1977 Mar;27(2):239-49. doi: 10.1111/j.1440-1827.1977.tb01873.x.
Characteristic pulmonary findings in an autopsy case of a 46-year-old female who presented heavy dyspnea as her chief complaint after 3 months of busulfan therapy for chronic myeloid leukemia were reported. The pulmonary findings were classified into four types: I. alveolar proteinosis type, II. intra alveolar fibrosis type, III. interstitial fibrosis type, and IV. lipid pneumonia type with cholesterol granuloma. No other case with various findings like this case has been previously reported. It was considered that type I is the basic type, type II is a type that developed from type I, type III is a type with interstitial cell infiltration and fibrosis and type IV is a lipidrich variant of type I. A large lamellar body was first found in the granular material of type I. It is supposed that such a body consists of osmiophilic body which originated from type B alveolar epithelial cells and blood plasma.
报告了一例46岁女性尸检病例的特征性肺部表现。该女性在接受白消安治疗慢性髓性白血病3个月后，以重度呼吸困难为主诉就诊。肺部表现分为四种类型：I.肺泡蛋白沉积症型；II.肺泡内纤维化型；III.间质纤维化型；IV.伴有胆固醇肉芽肿的脂质性肺炎型。此前未见有其他病例出现如此多样的表现。据认为，I型是基本类型，II型是由I型发展而来的类型，III型是伴有间质细胞浸润和纤维化的类型，IV型是I型的富含脂质变体。在I型的颗粒物质中首次发现了大的板层小体。推测这样的小体由源自B型肺泡上皮细胞的嗜锇小体和血浆组成。
