Aymard J P, Gyger M, Lavallee R, Legresley L P, Desy M
Cancer. 1984 Feb 15;53(4):954-6. doi: 10.1002/1097-0142(19840215)53:4<954::aid-cncr2820530422>3.0.co;2-q.
A 34-year-old woman with typical chronic myelogenous leukemia was treated with daily busulfan (total dose, 1600 mg approximately) from July 1978 to June 1981. In February 1981, she noticed a progressive deterioration of her clinical status, characterized by increasing dyspnea and productive cough. In July 1981, an open lung biopsy revealed pulmonary alveolar proteinosis. The patient died of progressive respiratory failure in August 1981. The association between chronic myelogenous leukemia and pulmonary alveolar proteinosis is briefly reviewed. The report discusses the possible etiologic role of busulfan therapy in the development of pulmonary alveolar proteinosis.
一名34岁患有典型慢性粒细胞白血病的女性，于1978年7月至1981年6月接受了每日白消安治疗（总剂量约1600毫克）。1981年2月，她注意到自己的临床状况逐渐恶化，表现为呼吸困难加重和咳痰。1981年7月，一次开放性肺活检显示为肺泡蛋白沉积症。该患者于1981年8月死于进行性呼吸衰竭。本文简要回顾了慢性粒细胞白血病与肺泡蛋白沉积症之间的关联。该报告讨论了白消安治疗在肺泡蛋白沉积症发生过程中可能的病因学作用。
