Duran-Struuck Raimon, Matar Abraham J, Huang Christene A
Department of Pathobiology, University of Pennsylvania School of Veterinary Medicine, Philadelphia PA, USA.
University of Central Florida College of Medicine, Orlando FL, USA.
Front Genet. 2015 Nov 20;6:332. doi: 10.3389/fgene.2015.00332. eCollection 2015.
The lack of a large animal transplantable tumor model has limited the study of novel therapeutic strategies for the treatment of liquid cancers. Swine as a species provide a natural option based on their similarities with humans and their already extensive use in biomedical research. Specifically, the Massachusetts General Hospital miniature swine herd retains unique genetic characteristics that facilitate the study of hematopoietic cell and solid organ transplantation. Spontaneously arising liquid cancers in these swine, specifically myeloid leukemias and B cell lymphomas, closely resemble human malignancies. The ability to establish aggressive tumor cell lines in vitro from these naturally occurring malignancies makes a transplantable tumor model a close reality. Here, we discuss our experience with myeloid and lymphoid tumors in major histocompatibility characterized miniature swine and future approaches regarding the development of a large animal transplantable tumor model.
缺乏大型动物可移植肿瘤模型限制了对液体癌症新型治疗策略的研究。猪作为一个物种，因其与人类的相似性以及在生物医学研究中的广泛应用，提供了一个自然的选择。具体而言，麻省总医院的小型猪群具有独特的遗传特征，便于研究造血细胞和实体器官移植。这些猪自发产生的液体癌症，特别是髓系白血病和B细胞淋巴瘤，与人类恶性肿瘤极为相似。从这些自然发生的恶性肿瘤中体外建立侵袭性肿瘤细胞系的能力，使得可移植肿瘤模型成为现实。在此，我们讨论了在主要组织相容性特征明确的小型猪中对髓系和淋巴系肿瘤的研究经验，以及关于大型动物可移植肿瘤模型开发的未来方法。
