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玻璃体腔注射贝伐单抗治疗放射性视网膜病变后黄斑水肿改善情况

Fellow Eye Macular Edema Improvement after Intravitreal Bevacizumab for Radiation Retinopathy.

作者信息

Brito Isis A S, Zacharias Leandro C, Pimentel Sérgio Luis G

机构信息

University of São Paulo, Rua Marieta Alves 116, 041815-260 Salvador, BA, Brazil.

出版信息

Case Rep Ophthalmol Med. 2015;2015:516921. doi: 10.1155/2015/516921. Epub 2015 Oct 8.

Abstract

Radiation retinopathy (RR) is a progressive, chronic condition directly related to the amount of radiation administered to the retina. We report a 37-year-old patient with medulloblastoma that was treated with external beam radiation and presented to us with bilateral cystoid macular edema. He was treated with monthly bevacizumab injections only in his worst seeing eye. There was a significant improvement in his fellow eye, with marked retinal thickness reduction. Therefore, we present clinical evidence of systemic absorption and fellow eye activity of the drug (bevacizumab). One must be aware of distant side effects after intravitreal injections.

摘要

放射性视网膜病变(RR)是一种与视网膜接受的辐射量直接相关的进行性慢性疾病。我们报告了一名37岁的髓母细胞瘤患者,该患者接受了外照射放疗,随后出现双侧黄斑囊样水肿前来就诊。我们仅对其视力最差的一只眼睛每月注射贝伐单抗进行治疗。其另一只眼睛有显著改善,视网膜厚度明显降低。因此,我们提供了该药物(贝伐单抗)全身吸收及对侧眼作用的临床证据。必须意识到玻璃体内注射后的远处副作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec2a/4617700/8ef4be910e39/CRIOPM2015-516921.001.jpg

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