Gundogan Fatih C, Akay Fahrettin, Uzun Salih, Ozge Gokhan, Toyran Sami, Genç Halil
Department of Ophthalmology, Gulhane Military Medical Academy, Ankara, Turkey.
Ophthalmologica. 2016;235(2):72-7. doi: 10.1159/000442216. Epub 2015 Dec 5.
The aim of this study was to evaluate choroidal thickness changes during acute attacks of familial Mediterranean fever (FMF).
Fifty patients with FMF and 50 healthy controls were included. Choroidal thickness of each participant was measured at the foveola and horizontal nasal and temporal quadrants at 500-µm intervals to 1,500 µm from the foveola using spectral-domain optical coherence tomography. White blood cell count, erythrocyte sedimentation rate (ESR) and serum levels of fibrinogen and C-reactive protein (CRP) were evaluated. The clinical findings (peritonitis, arthritis and pleuritis) were noted.
Choroidal thickness was significantly thicker at all measurement points in FMF patients compared to healthy controls during an acute attack (p < 0.05). There were positive correlations between the choroidal thickness and ESR, fibrinogen and, particularly, CRP levels. Clinical findings did not change the choroidal thickness significantly (p > 0.05).
Increased choroidal thickness in the acute phase of FMF is possibly related to the inflammatory edematous changes in the choroid.
本研究旨在评估家族性地中海热（FMF）急性发作期间脉络膜厚度的变化。
纳入50例FMF患者和50例健康对照。使用光谱域光学相干断层扫描，在每个参与者的黄斑中心凹以及从黄斑中心凹起以500μm间隔至1500μm的水平鼻侧和颞侧象限测量脉络膜厚度。评估白细胞计数、红细胞沉降率（ESR）以及纤维蛋白原和C反应蛋白（CRP）的血清水平。记录临床发现（腹膜炎、关节炎和胸膜炎）。
在急性发作期间，与健康对照相比，FMF患者在所有测量点的脉络膜厚度均显著增厚（p < 0.05）。脉络膜厚度与ESR、纤维蛋白原，尤其是CRP水平之间存在正相关。临床发现并未显著改变脉络膜厚度（p > 0.05）。
FMF急性期脉络膜厚度增加可能与脉络膜的炎性水肿变化有关。
