Pál T, Hale T L
Department of Enteric Infections, Walter Reed Army Institute of Research, Washington, D.C. 20307.
Infect Immun. 1989 Aug;57(8):2580-2. doi: 10.1128/iai.57.8.2580-2582.1989.
The initial interaction of Shigella flexneri with HeLa cells was studied at 4 degrees C, a temperature that inhibits parasite-directed endocytosis. It was found that invasive strains were 10-fold more adherent to HeLa cells than were isogenic, noninvasive strains which had lost a 140-megadalton plasmid. Adherent strains were also more hydrophobic than were nonadherent strains.
在4℃下研究了福氏志贺菌与HeLa细胞的初始相互作用,该温度会抑制寄生虫介导的内吞作用。结果发现,侵袭性菌株对HeLa细胞的黏附能力比失去140兆道尔顿质粒的同基因非侵袭性菌株高10倍。黏附性菌株也比非黏附性菌株更疏水。