细菌进入上皮细胞：志贺氏菌范例
Bacterial entry into epithelial cells: the paradigm of Shigella.
作者信息
Ménard R, Dehio C, Sansonetti P J
机构信息
Unité de Pathogénie Microbienne Moléculaire, Institut Pasteur, Paris, France.
出版信息
Trends Microbiol. 1996 Jun;4(6):220-6. doi: 10.1016/0966-842X(96)10039-1.
PMID:8795157
Abstract
Shigella flexneri is a model for the entry of bacterial pathogens into nonphagocytic epithelial cells. On contact with the epithelial cell surface, the Ipa proteins are secreted from the bacterium. The Ipa complex then triggers a reorganization of the host-cell cytoskeleton leading to the formation of membrane ruffles, which engulf the bacterium.
摘要
福氏志贺菌是细菌病原体进入非吞噬性上皮细胞的一个模型。与上皮细胞表面接触时，细菌会分泌Ipa蛋白。然后，Ipa复合物会引发宿主细胞细胞骨架的重组，导致膜皱褶形成，从而吞噬细菌。
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