Gao Rongbao, Bai Tian, Li Xiaodan, Xiong Ying, Huang Yiwei, Pan Ming, Zhang Ye, Bo Hong, Zou Shumei, Shu Yuelong
National Institute for Viral Disease Control and Prevention Chinese Center for Disease Control and Prevention, Key Laboratory for Medical Virology, National Health and Family Planning Commission, Beijing 102206, China.
Jiangxi Provincial Disease Control and Prevention, Nanchang 330029, China.
Virology. 2016 Jan 15;488:149-55. doi: 10.1016/j.virol.2015.11.013. Epub 2015 Nov 28.
H9N2 avian influenza virus circulates widely in poultry and has been responsible for sporadic human infections in several regions. Few studies have been conducted on the pathogenicity of H9N2 AIV isolates that have different genomic features. We compared the pathology induced by a novel reassortant H9N2 virus and two currently circulating H9N2 viruses that have different genomic features in ferrets. The results showed that the three viruses can induce infections with various amounts of viral shedding in ferrets. The novel H9N2 induced respiratory infection, but no pathological lesions were observed in lung tissues. The other two viruses induced mild to intermediate pathological lesions in lung tissues, although the clinical signs presented mildly in ferrets. The pathological lesions presented a diversity consistent with viral replication in ferrets.
H9N2禽流感病毒在禽类中广泛传播，并在多个地区导致了散发性人类感染。针对具有不同基因组特征的H9N2禽流感病毒分离株的致病性，开展的研究较少。我们比较了一种新型重配H9N2病毒和两种目前正在传播的具有不同基因组特征的H9N2病毒在雪貂体内诱发的病理学变化。结果显示，这三种病毒均可在雪貂体内诱发不同程度的病毒脱落感染。新型H9N2病毒诱发了呼吸道感染，但在肺组织中未观察到病理损伤。另外两种病毒在肺组织中诱发了轻度至中度的病理损伤，尽管雪貂的临床症状表现较轻。病理损伤呈现出与雪貂体内病毒复制相一致的多样性。
