Voronkova Ya G, Popova T N, Agarkov A A, Skulachev M V
Voronezh State University, Department of Medical Biochemistry and Microbiology, Voronezh, 394006, Russia.
Biochemistry (Mosc). 2015 Dec;80(12):1606-13. doi: 10.1134/S0006297915120093.
An influence of 10-(6'-plastoquinonyl)decyltriphenylphosphonium (SkQ1) on oxidative status and activity of some antioxidant enzymes in the liver and blood serum from rats was examined during experimental hyperglycemia developed after injecting protamine sulfate. It was found that SkQ1 lowered glycemic level in rats treated with protamine sulfate. Moreover, it was also accompanied by restoration of the normal range of biochemiluminescence parameters indicating the rate of ongoing free radical processes, magnitude of primary products of lipid peroxidation such as diene conjugates, activity of aconitate hydratase, and level of citrate in rat liver and blood. Hence, it was demonstrated that activity of superoxide dismutase and catalase, increasing during hyperglycemia, was decreased after administering SkQ1. This might be related to the ability of SkQ1 to normalize free-radical homeostasis imbalanced during hyperglycemia.
在注射硫酸鱼精蛋白后引发的实验性高血糖期间，研究了10-(6'-质体醌基)癸基三苯基鏻(SkQ1)对大鼠肝脏和血清中氧化状态及某些抗氧化酶活性的影响。结果发现，SkQ1降低了硫酸鱼精蛋白处理的大鼠的血糖水平。此外，还伴随着生物化学发光参数恢复到正常范围，这些参数表明自由基过程的进行速率、脂质过氧化初级产物如二烯共轭物的量、乌头酸水合酶的活性以及大鼠肝脏和血液中柠檬酸的水平。因此，证明了在高血糖期间增加的超氧化物歧化酶和过氧化氢酶的活性，在给予SkQ1后降低。这可能与SkQ1使高血糖期间失衡的自由基稳态正常化的能力有关。
