Petrenko O Iu, Sosimchyk I O, Cherkashyna D V, Semenchenko O A, Skulachov V P
Ukr Biokhim Zh (1999). 2009 Nov-Dec;81(6):43-8.
The influence of mitochondria-targeted antioxidant 10-(6-plastoquinonyl)decyltriphenylphosphonium (SkQ,) different concentrations on respiratory parameters and lipid peroxidation process intensity in the rat liver after hypothermic storage was investigated. It was shown that cold storage of isolated liver during 18 h results in accumulation of TBA-active products, increase of intensity of Fe(2+)-ascorbate induced lipid peroxidation and depression of mitochondria functional activity. SkQ1 inhibits activation of free radical processes in a dose-dependent manner and it has a positive influence on energetic coupling in mitochondria.
研究了线粒体靶向抗氧化剂10-(6-质体醌基)癸基三苯基鏻(SkQ1)不同浓度对低温保存后大鼠肝脏呼吸参数和脂质过氧化过程强度的影响。结果表明，离体肝脏冷藏18小时会导致TBA活性产物积累、Fe(2+)-抗坏血酸诱导的脂质过氧化强度增加以及线粒体功能活性降低。SkQ1以剂量依赖的方式抑制自由基过程的激活，并对线粒体中的能量偶联有积极影响。
