Division of Neurodegenerative Diseases, Department of Neurology, Technische Universität Dresden, Dresden, Germany.
Department of Neurology, University of Rostock, Rostock, Germany.
J Parkinsons Dis. 2015;5(4):737-41. doi: 10.3233/JPD-150656.
Nonmotor symptoms (NMS) fluctuate in conjunction with motor oscillations in advanced Parkinson's disease (PD), though little is known about the variability of NMS fluctuations in individual patients. We aimed to assess within-patient variability in frequency and severity of NMS during a series of five patient-perceived motor On and Off periods in 38 fluctuating PD patients from the multicenter NonMotorFluctuations in PD study using a visual analogue scale. NMS frequency and severity appeared moderately variable in both motor states within individual patients. Symptom severity ranges between motor states showed high variability and were larger in motor Off states for most NMS.
非运动症状（NMS）在晚期帕金森病（PD）中与运动波动同步变化，但个体患者 NMS 波动的可变性知之甚少。我们旨在使用视觉模拟量表评估 38 名多中心非运动波动 PD 研究中的波动 PD 患者连续五次患者感知的运动 ON 和 OFF 期间 NMS 的频率和严重程度的个体内变异性。在个体患者的两种运动状态中，NMS 的频率和严重程度均表现出中度可变性。运动状态之间的症状严重程度范围具有高度可变性，且对于大多数 NMS，在运动 OFF 状态下更大。
