Boura Iro, Poplawska-Domaszewicz Karolina, Spanaki Cleanthe, Chen Rosabel, Urso Daniele, van Coller Riaan, Storch Alexander, Chaudhuri Kallol Ray
School of Medicine, University of Crete, Heraklion, Greece.
Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
J Mov Disord. 2025 Jan;18(1):1-16. doi: 10.14802/jmd.24227. Epub 2024 Dec 20.
Non-motor fluctuations (NMFs) in Parkinson's disease (PD) significantly affect patients' well-being. Despite being identified over two decades ago, NMFs remain largely underrecognized, undertreated, and poorly understood. While they are often temporally associated with motor fluctuations (MFs) and can share common risk factors and pathophysiologic mechanisms, NMFs and MFs are currently considered distinct entities. The prevalence and severity of NMFs, often categorized into neuropsychiatric, sensory, and autonomic subtypes, vary significantly across studies due to the heterogeneous PD populations screened and the diverse evaluation tools applied. The consistent negative impact of NMFs on PD patients' quality of life underscores the importance of further investigations via focused and controlled studies, validated assessment instruments and novel digital technologies. High-quality research is essential to illuminate the complex pathophysiology and clinical nuances of NMFs, ultimately enhancing clinicians' diagnostic and treatment options in routine clinical practice.
帕金森病（PD）中的非运动波动（NMFs）显著影响患者的生活质量。尽管NMFs在二十多年前就已被发现，但在很大程度上仍未得到充分认识、治疗和理解。虽然它们通常在时间上与运动波动（MFs）相关，并且可能有共同的风险因素和病理生理机制，但目前认为NMFs和MFs是不同的实体。由于所筛查的帕金森病患者群体异质性以及所应用的评估工具多样，常被分为神经精神、感觉和自主神经亚型的NMFs的患病率和严重程度在各项研究中差异很大。NMFs对帕金森病患者生活质量持续的负面影响凸显了通过有针对性的对照研究、经过验证的评估工具和新型数字技术进行进一步调查的重要性。高质量的研究对于阐明NMFs复杂的病理生理学和临床细微差别至关重要，最终可增加临床医生在常规临床实践中的诊断和治疗选择。
