Reyes Eliana
Nuclear Medicine Department, Royal Brompton Hospital, London, SW3 6NP, UK.
Harefield Hospital, Hill End Road, Harefield, Middlesex, UB9 6JH, UK.
Future Cardiol. 2016 Jan;12(1):59-67. doi: 10.2217/fca.15.70. Epub 2015 Dec 7.
Noninvasive functional imaging plays a major role in the diagnosis of hemodynamically significant coronary artery disease (CAD) by means of the detection of abnormal myocardial perfusion. For this, cardiac stressors are essential as they induce hypoperfusion in the presence of flow-limiting coronary stenosis. Several pharmacological stressors are currently available and it is important that clinicians who are involved in the care and management of patients with CAD become familiar with their indications, contraindications and protocols. Among the primary coronary vasodilator agents, regadenoson is increasingly used as the default stressor or as an alternative to other modalities of stress. This article provides an updated review of regadenoson stress for the assessment of patients with suspected or known CAD and describes its pharmacological properties, stress protocol, efficacy and safety profile.
无创功能成像通过检测心肌灌注异常在血流动力学显著的冠状动脉疾病（CAD）诊断中发挥着重要作用。为此，心脏应激源至关重要，因为它们在存在血流受限的冠状动脉狭窄时会诱发灌注不足。目前有几种药物应激源可供使用，参与CAD患者护理和管理的临床医生熟悉其适应证、禁忌证和方案非常重要。在主要的冠状动脉血管扩张剂中，瑞加德松越来越多地被用作默认应激源或其他应激方式的替代物。本文提供了关于瑞加德松应激用于评估疑似或已知CAD患者的最新综述，并描述了其药理特性、应激方案、疗效和安全性概况。
