Mukherjee A, Misra R S, Meyers W M
Institute of Pathology-I.C.M.R., Safdarjang Hospital, New Delhi, India.
Int J Lepr Other Mycobact Dis. 1989 Jun;57(2):506-10.
The dermal lymphatic vessels in lepromatous and tuberculoid leprosy lesions were studied by light- and electron-microscopy. In the lepromatous patient, lymphatic vessels were seen in both intra- and peri-granulomatous areas. The lymphatic lining cells contained lipid droplets, lysosomes, and numerous pinocytotic vesicles. Cells bearing bacilli were only occasionally seen. In the tuberculoid cases, lymphatic vessels were seen only along the edges of the granulomas and the lining cells were less prominent. Inflammatory cells, both lymphocytes and histiocytes, were found traversing the walls of lymphatic vessels in both groups of patients. The results of the study confirm the continued and increased functioning of the lymphatic drainage system in dermal leprosy lesions, and indicates that it may be a major route for the clearance of lipids from the lipid-rich bacilliferous lesions in the lepromatous patient. The lymphatic pathway appears to be a minor pathway for the dissemination of Mycobacterium leprae in comparison with the blood vascular system.
通过光学显微镜和电子显微镜对瘤型和结核样型麻风病变中的皮肤淋巴管进行了研究。在瘤型麻风患者中，在肉芽肿内和肉芽肿周围区域均可见淋巴管。淋巴管内衬细胞含有脂滴、溶酶体和大量吞饮小泡。仅偶尔可见携带杆菌的细胞。在结核样型病例中，仅在肉芽肿边缘可见淋巴管，且内衬细胞不那么突出。在两组患者中均发现淋巴细胞和组织细胞等炎性细胞穿过淋巴管壁。研究结果证实了皮肤麻风病变中淋巴引流系统持续且增强的功能，并表明它可能是瘤型麻风患者富含脂质的带菌病变中脂质清除的主要途径。与血管系统相比，淋巴途径似乎是麻风杆菌传播的次要途径。
