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决明子种子多糖的提取、表征及分子量测定

Extraction, Characterization, and Molecular Weight Determination of Senna tora (L.) Seed Polysaccharide.

作者信息

Pawar Harshal A, Lalitha K G

机构信息

Department of Quality Assurance, Dr. L. H. Hiranandani College of Pharmacy, Ulhasnagar, Maharashtra 421003, India.

Department of Pharmaceutical Chemistry, Ultra College of Pharmacy, No. 4/235, College Road, Thasildar Nagar, Madurai, Tamil Nadu 625020, India.

出版信息

Int J Biomater. 2015;2015:928679. doi: 10.1155/2015/928679. Epub 2015 Nov 12.

DOI:10.1155/2015/928679
PMID:26640490
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4660029/
Abstract

The objective of the present work was extraction of polysaccharide from Senna tora L. seed and its characterization as a pharmaceutical excipient. Polysaccharide extraction was based on mechanical separation of the endosperm of seeds of Senna tora, water dissolution, centrifugation, and precipitation with acetone. Standard procedures were used to study the viscosity, micromeritic properties, and microbial bioburden. Accelerated stability study was carried out on isolated polysaccharide for six months at 40°C/75 RH as per ICH guidelines. The gum obtained from S. tora seeds was an amorphous free flowing odourless powder with dull brown colour (yield = 35% w/w). The bulk density, tapped density, and angle of repose data reveal that S. tora gum possesses good flow property. The intrinsic viscosity obtained was 1.568 dL/g. The average molecular weight of purified S. tora gum was found to be 198 kDa by intrinsic viscosity method. The results indicated that viscosity of gum solution increases with increase in temperature. FTIR study revealed the absence of degradation or decomposition of polysaccharide at accelerated stability conditions for six months. It has been concluded that extracted polysaccharide can be used as pharmaceutical excipient in terms of flow behavior, microbial properties, and stability.

摘要

本研究的目的是从决明子种子中提取多糖，并将其表征为药用辅料。多糖提取基于决明子种子胚乳的机械分离、水溶解、离心以及丙酮沉淀。采用标准程序研究粘度、粉体学性质和微生物生物负荷。按照国际协调会议（ICH）指南，在40°C/75%相对湿度条件下对分离出的多糖进行了为期六个月的加速稳定性研究。从决明子种子中获得的胶为无定形、自由流动、无味的暗棕色粉末（产率=35%w/w）。堆密度、振实密度和休止角数据表明决明子胶具有良好的流动性能。测得的特性粘度为1.568 dL/g。通过特性粘度法测得纯化的决明子胶的平均分子量为198 kDa。结果表明，胶溶液的粘度随温度升高而增加。傅里叶变换红外光谱（FTIR）研究表明，在加速稳定性条件下放置六个月后，多糖没有降解或分解。得出的结论是，就流动行为、微生物性质和稳定性而言，提取的多糖可作为药用辅料。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/27f1/4660029/99db766bbb88/IJBM2015-928679.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/27f1/4660029/6f9c77c749aa/IJBM2015-928679.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/27f1/4660029/4e1c17397ae5/IJBM2015-928679.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/27f1/4660029/42dae995f94d/IJBM2015-928679.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/27f1/4660029/9bef81100c83/IJBM2015-928679.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/27f1/4660029/99db766bbb88/IJBM2015-928679.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/27f1/4660029/6f9c77c749aa/IJBM2015-928679.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/27f1/4660029/4e1c17397ae5/IJBM2015-928679.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/27f1/4660029/42dae995f94d/IJBM2015-928679.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/27f1/4660029/9bef81100c83/IJBM2015-928679.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/27f1/4660029/99db766bbb88/IJBM2015-928679.005.jpg

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