Tomizawa Minoru, Shinozaki Fuminobu, Fugo Kazunori, Hasegawa Rumiko, Shirai Yoshinori, Motoyoshi Yasufumi, Sugiyama Takao, Yamamoto Shigenori, Kishimoto Takashi, Ishige Naoki
Department of Gastroenterology, National Hospital Organization Shimoshizu Hospital, Yotsukaido, Chiba 284-0003, Japan.
Department of Radiology, National Hospital Organization Shimoshizu Hospital, Yotsukaido, Chiba 284-0003, Japan.
Exp Ther Med. 2015 Nov;10(5):1835-1839. doi: 10.3892/etm.2015.2718. Epub 2015 Sep 1.
Gastric cancer is occasionally diagnosed using transabdominal ultrasonography (US) during screening or investigation of patients with abdominal symptoms. Therefore, the present study analyzed the association of the tumor diameter, pathological T (pT) staging and depth of invasion with the detection of gastric cancer using US. Patient records were analyzed retrospectively and 13 patients were enrolled, who underwent US screening prior to endoscopic mucosal resection, endoscopic submucosal dissection or surgery. In total, 5 patients were diagnosed with gastric cancer using US (positive detection group), while US was unable to detect the gastric cancer in 8 patients (negative detection group). The tumor diameter and depth of invasion were determined by pathologists. One-way analysis of variance or the χ test was performed. Wall thickness in gastric cancer cases ranged between 7 and 20 mm (mean, 12.2±5.9 mm), as measured using abdominal US. The hemoglobin level was significantly lower in the positive detection patients compared with the negative detection patients (P=0.0455). In addition, the diameters of the gastric wall in the negative and positive detection patients were 24.5±16.4 and 54.4±26.2 mm, respectively (P=0.0266). These results indicate that gastric cancer in the positive detection patients were at a more advanced-stage compared with that in the negative detection patients. Furthermore, gastric cancer with a stage over pT2 was diagnosed using abdominal US (P=0.0242), whereas stage pT1a gastric cancer was not detected by abdominal US. Gastric tumors invading deeper than the submucosa were diagnosed using US (P=0.0242). However, the gastric cancer cases limited to the mucosa remained undetected. In conclusion, the detection of gastric cancer correlated well with the tumor diameter, pT staging and depth of invasion.
在对有腹部症状的患者进行筛查或检查时，偶尔会通过经腹超声（US）诊断出胃癌。因此，本研究分析了肿瘤直径、病理T（pT）分期和浸润深度与使用US检测胃癌之间的关联。对患者记录进行回顾性分析，纳入了13例在内镜黏膜切除术、内镜黏膜下剥离术或手术前接受US筛查的患者。总共5例患者通过US诊断为胃癌（阳性检测组），而8例患者US未能检测出胃癌（阴性检测组）。肿瘤直径和浸润深度由病理学家确定。进行了单因素方差分析或χ检验。使用腹部US测量，胃癌病例的胃壁厚度在7至20毫米之间（平均为12.2±5.9毫米）。阳性检测患者的血红蛋白水平显著低于阴性检测患者（P = 0.0455）。此外，阴性和阳性检测患者的胃壁直径分别为24.5±16.4和54.4±26.2毫米（P = 0.0266）。这些结果表明，与阴性检测患者相比，阳性检测患者的胃癌处于更晚期阶段。此外，使用腹部US诊断出pT2期以上的胃癌（P = 0.0242），而腹部US未检测出pT1a期胃癌。浸润深度超过黏膜下层的胃肿瘤可通过US诊断（P = 0.0242）。然而，局限于黏膜层的胃癌病例未被检测到。总之，胃癌的检测与肿瘤直径、pT分期和浸润深度密切相关。
