MacAskill Michael R, Anderson Tim J
aNew Zealand Brain Research Institute bDepartment of Medicine, University of Otago cDepartment of Neurology, Christchurch Hospital, Christchurch, New Zealand.
Curr Opin Neurol. 2016 Feb;29(1):61-8. doi: 10.1097/WCO.0000000000000274.
Abnormalities of oculomotor control accompany the pathological changes underlying many neurodegenerative diseases. Clinical examination of eye movements can contribute to differential diagnosis, whereas quantitative laboratory measures can provide detailed insight into the disease process. In this review of eye movements in neurodegenerative disease, we summarise recent empirical findings and conceptual advances.
Oculomotor researchers continue to be particularly prolific in studying Parkinson's disease but there is also substantial activity in Alzheimer's disease and spinocerebellar ataxia. Interesting findings have been reported in Huntington's, motor neuron disease, and glaucoma. Most studies report laboratory-based investigations but useful progress in clinical description continues to be made.
Eye movements remain an active field of investigation across a variety of neurodegenerative conditions. Progress continues to be made at the clinical level as well by using laboratory techniques.
眼球运动控制异常伴随着许多神经退行性疾病的病理变化。眼动的临床检查有助于鉴别诊断，而定量实验室测量可深入了解疾病进程。在这篇关于神经退行性疾病中眼动的综述中，我们总结了近期的实证研究结果和概念进展。
眼球运动研究人员在帕金森病研究方面仍然成果颇丰，但在阿尔茨海默病和脊髓小脑共济失调方面也有大量研究活动。在亨廷顿病、运动神经元病和青光眼方面也报告了有趣的发现。大多数研究报告的是基于实验室的调查，但临床描述方面也在不断取得有益进展。
在各种神经退行性疾病中，眼动仍然是一个活跃的研究领域。通过使用实验室技术，临床层面也在不断取得进展。
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