Karri Veera Venkata Satyanarayana Reddy, Kuppusamy Gowthamarajan, Talluri Siddhartha Venkata, Yamjala Karthik, Mannemala Sai Sandeep, Malayandi Rajkumar
a a Department of Pharmaceutics, JSS College of Pharmacy, Ootacamund , JSS University , Mysore , India.
b b Department of Pharmaceutical Analysis, JSS College of Pharmacy, Ootacamund , JSS University , Mysore , India.
Curr Med Res Opin. 2016;32(3):519-42. doi: 10.1185/03007995.2015.1128888. Epub 2016 Jan 12.
Diabetic foot ulcers are one of the major causes of mortality in diabetic patients. Very few drugs and therapies have regulatory approval for this indication and several agents from diverse pharmacological classes are currently in various phases of clinical trials for the management of diabetic foot ulcers.
The purpose of this review is to provide concise information of the drugs and therapies which are approved and present in clinical trials.
This review was carried out by systematic searches of relevant guidelines, patents, published articles, reviews and abstracts in PubMed/Medline, Web of Science, clinicaltrials.gov, Cochrane Central Register of Controlled Trials, Cochrane Database of Systematic Reviews and Google Scholar of all English language articles up to 1 March 2015. The following search terms were used: diabetes, diabetic foot, diabetic foot ulcer, diabetic wound, diabetic foot infections, wound management, randomized controlled trials, approved treatments, new treatments and clinical trials.
The various drugs and therapies for the management of diabetic foot ulcers comprise antibiotics, neuropathic drugs, wound dressings, skin substitutes, growth factors and inflammatory modulators. The majority of these therapies target the treatment of diabetic foot ulcers to address the altered biochemical composition of the diabetic wound. However, no single treatment can be definitively recommended for the treatment of diabetic foot ulcers.
糖尿病足溃疡是糖尿病患者死亡的主要原因之一。针对这一适应症，仅有极少数药物和疗法获得了监管批准，目前来自不同药理学类别的几种药物正处于治疗糖尿病足溃疡的临床试验的不同阶段。
本综述的目的是提供已获批准并正在进行临床试验的药物和疗法的简要信息。
本综述通过系统检索相关指南、专利、已发表文章、综述以及截至2015年3月1日在PubMed/Medline、科学网、clinicaltrials.gov、Cochrane对照试验中心注册库、Cochrane系统评价数据库和谷歌学术上的所有英文文章摘要进行。使用了以下检索词：糖尿病、糖尿病足、糖尿病足溃疡、糖尿病伤口、糖尿病足感染、伤口处理、随机对照试验、已批准的治疗方法、新治疗方法和临床试验。
用于治疗糖尿病足溃疡的各种药物和疗法包括抗生素、神经病变药物、伤口敷料、皮肤替代物、生长因子和炎症调节剂。这些疗法大多针对糖尿病足溃疡的治疗，以解决糖尿病伤口改变的生化组成问题。然而，对于糖尿病足溃疡的治疗，尚无单一治疗方法可被明确推荐。
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