定植菌群与糖尿病创面愈合的临床结局相关。
Colonizing microbiota is associated with clinical outcomes in diabetic wound healing.
机构信息
Department of Plastic and Aesthetic Surgery, Nanfang Hospital of Southern Medical University, Guangzhou, Guangdong Province 510515, China; Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD 21210, USA.
Department of Plastic and Aesthetic Surgery, Nanfang Hospital of Southern Medical University, Guangzhou, Guangdong Province 510515, China.
出版信息
Adv Drug Deliv Rev. 2023 Mar;194:114727. doi: 10.1016/j.addr.2023.114727. Epub 2023 Feb 8.
With the development of society and the improvement of life quality, more than 500 million people are affected by diabetes. More than 10 % of people with diabetes will suffer from diabetic wounds, and 80 % of diabetic wounds will reoccur, so the development of new diabetic wound treatments is of great importance. The development of skin microbe research technology has gradually drawn people's attention to the complex relationship between microbes and diabetic wounds. Many studies have shown that skin microbes are associated with the outcome of diabetic wounds and can even be used as one of the indicators of wound prognosis. Skin microbes have also been found to have the potential to treat diabetic wounds. The wound colonization of different bacteria can exert opposing therapeutic effects. It is necessary to fully understand the skin microbes in diabetic wounds, which can provide valuable guidance for clinical diabetic wound treatment.
随着社会的发展和生活质量的提高，超过 5 亿人受到糖尿病的影响。超过 10%的糖尿病患者会患有糖尿病性伤口，而 80%的糖尿病性伤口会再次发生，因此开发新的糖尿病性伤口治疗方法非常重要。皮肤微生物研究技术的发展逐渐引起人们对微生物与糖尿病性伤口之间复杂关系的关注。许多研究表明，皮肤微生物与糖尿病性伤口的结果有关，甚至可以作为伤口预后的指标之一。已经发现皮肤微生物具有治疗糖尿病性伤口的潜力。不同细菌的伤口定植可以发挥相反的治疗效果。充分了解糖尿病性伤口中的皮肤微生物可以为临床糖尿病性伤口治疗提供有价值的指导。
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