Liu Xing, Wang Chen
State Key Laboratory of Cell Biology, Innovation Centre for Cell Signalling Network, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China.
Program in Cellular and Molecular Medicine, Boston Children's Hospital and Department of Pediatrics, Harvard Medical School, Boston, MA, USA.
Immunology. 2016 Mar;147(3):285-91. doi: 10.1111/imm.12561. Epub 2015 Dec 27.
DNA that gains access to the cytoplasm generally serves as a danger signal for the hosts. An emerging paradigm for responding to cytosolic DNAs centres on the endoplasmic reticulum-resident protein stimulator of interferon genes (STING, also known as MITA, ERIS or MPYS), the hub adaptor of the recently identified DNA sensors. Dynamic regulations of STING action are critical for shaping innate immune responses against microbial infections, as well as for preventing autoimmune diseases. STING is also indispensable for the detection of immunogenic tumours. A deeper understanding of STING modulations could be instrumental for developing novel immunotherapeutic strategies against infectious, autoimmune and cancerous diseases. In this review, we summarize the latest advances on the role of STING in the DNA-triggered immune reactions, and underscore the critical issues that remain to be resolved in future studies.
进入细胞质的DNA通常对宿主而言是一种危险信号。应对胞质DNA的一种新兴模式聚焦于内质网驻留蛋白——干扰素基因刺激因子（STING，也称为MITA、ERIS或MPYS），它是最近发现的DNA传感器的核心衔接蛋白。STING作用的动态调节对于塑造针对微生物感染的固有免疫反应以及预防自身免疫性疾病至关重要。STING对于免疫原性肿瘤的检测也不可或缺。更深入地了解STING调节可能有助于开发针对感染性、自身免疫性和癌性疾病的新型免疫治疗策略。在本综述中，我们总结了STING在DNA触发的免疫反应中的作用的最新进展，并强调了未来研究中仍有待解决的关键问题。
