Almeida Osvaldo P, McCaul Kieran, Hankey Graeme J, Yeap Bu B, Golledge Jonathan, Flicker Leon
School of Psychiatry and Clinical Neurosciences, University of Western Australia, Australia.
WA Centre for Health and Ageing, Centre for Medical Research, Australia.
Addict Biol. 2017 Mar;22(2):570-578. doi: 10.1111/adb.12340. Epub 2015 Dec 8.
We designed this cohort study of men aged 70-89 years to determine if excessive alcohol use increases mortality. They reported history of alcohol use (never, past, ≤ two daily drinks, two to four daily drinks, four to six daily drinks, > six daily drinks) and donated a blood sample in 2001-2004. We determined the ADH1B rs1229984 G>A polymorphism and retrieved mortality data from the Western Australian Data Linkage System. Other study measures included age, education, body mass index, smoking, and history of hypertension, diabetes, chronic respiratory diseases, coronary heart disease and stroke. Of the 3496 participants, 225 (6.4 percent) carried the ADH1B rs1229984 G>A polymorphism. Carriers consumed significantly less alcohol than non-carriers. The adjusted mortality hazard ratio (MHR, 95 percent confidence interval-95%CI) over 8.0 years (range: 10 weeks to 11.2 years) relative to never drinkers was 1.15 (95%CI = 0.86, 1.55) for past drinkers, 0.98 (95%CI = 0.76, 1.25) for men consuming ≤ two daily drinks, 1.13 (95%CI = 0.85, 1.49) for two to four drinks, 1.18 (95%CI = 0.81, 1.71) for four to six drinks and 1.87 (95%CI = 1.11, 3.12) for those consuming more than six daily drinks on a regular basis. The MHR associated with the ADH1B rs1229984 G>A polymorphism was 0.68 (95%CI = 0.54, 0.87). Excessive alcohol use in later life is associated with increased mortality, and this association is likely to be causal. We found no evidence that light to moderate alcohol use decreases the mortality of older men. Health messages regarding the safe use of alcohol in older age may benefit from taking these findings into account.
我们设计了这项针对70至89岁男性的队列研究，以确定过量饮酒是否会增加死亡率。他们报告了饮酒史（从不饮酒、过去饮酒、每天饮酒≤两杯、每天饮酒2至4杯、每天饮酒4至6杯、每天饮酒>6杯），并于2001年至2004年捐献了血样。我们确定了乙醇脱氢酶1B（ADH1B）基因rs1229984位点G>A多态性，并从西澳大利亚数据链接系统中检索了死亡率数据。其他研究指标包括年龄、教育程度、体重指数、吸烟情况，以及高血压、糖尿病、慢性呼吸道疾病、冠心病和中风病史。在3496名参与者中，225人（6.4%）携带ADH1B基因rs1229984位点G>A多态性。携带者的饮酒量明显低于非携带者。在8.0年（范围：10周至11.2年）期间，相对于从不饮酒者，过去饮酒者的校正死亡率风险比（MHR，95%置信区间-95%CI）为1.15（95%CI = 0.86，1.55），每天饮酒≤两杯的男性为0.98（95%CI = 0.76，1.25），每天饮酒2至4杯的男性为1.13（95%CI = 0.85，1.49），每天饮酒4至6杯的男性为1.18（95%CI = 0.81，1.71），经常每天饮酒超过6杯的男性为1.87（95%CI = 1.11，3.12）。与ADH1B基因rs1229984位点G>A多态性相关的MHR为0.68（95%CI = 0.54，0.87）。晚年过量饮酒与死亡率增加相关，且这种关联可能是因果关系。我们没有发现证据表明少量至适量饮酒会降低老年男性的死亡率。考虑到这些发现，关于老年人安全饮酒的健康信息可能会从中受益。
