Hashimoto Marowa, Watanabe Masutaka, Uematsu Yuji, Hattori Sonomi, Miyai Nobuyuki, Utsumi Miyoko, Oka Mayumi, Hayashida Mariko, Kinoshita Kenji, Arita Mikio, Takeshita Tatsuya
Department of Public Health, School of Medicine, Wakayama Medical University, 811-1 Kimiidera, Wakayama, Wakayama, 641-8509, Japan.
School of Health and Nursing Sciences, Wakayama Medical University, Wakayama, Wakayama, Japan.
Environ Health Prev Med. 2016 May;21(3):138-48. doi: 10.1007/s12199-016-0507-5. Epub 2016 Jan 29.
Many East Asians have the genetic polymorphisms rs1229984 in alcohol dehydrogenase 1B (ADH1B) and rs671 in aldehyde dehydrogenase 2 (ALDH2). Here we analyzed the relationships of the two genotypes with alcohol sensitivity, drinking behavior and problem drinking among older and younger men living in rural areas of Japan.
The subjects were 718 Japanese men aged 63.3 ± 10.8 (mean ± SD), categorized into the older (≥65 years, n = 357) and younger (<65 years, n = 361) groups. Facial flushing frequency, drinking behavior and positive CAGE results were compared among the genotypes using Bonferroni-corrected χ(2) test and a multivariate logistic regression analysis adjusting for age, BMI and lifestyle factors.
The frequency of 'always' facial flushing among the ADH1B*1/2 carriers was significantly lower than that among the ADH1B2/2 carriers in the older group (P < 0.01). The alcohol consumption (unit/day) in the ADH1B1/2 carriers tended to be higher compared with that in the ADH1B2/2 carriers among the older group (P = 0.050). In the younger group, no significant differences in alcohol sensitivity and drinking habits were generally found among the ADH1B genotypes. The ADH1B1/*1 genotype tended to be positively associated with problem drinking in the older group (P = 0.080) but not in the younger group. The ALDH2 genotypes consistently and strongly affected the alcohol sensitivity, drinking behavior and problem drinking in both the younger and older group.
We for the first time observed a significant difference in alcohol sensitivity between ADH1B*1/2 and ADH1B2/*2 in older men aged 65 and above.
许多东亚人存在酒精脱氢酶1B（ADH1B）基因多态性rs1229984和乙醛脱氢酶2（ALDH2）基因多态性rs671。在此，我们分析了这两种基因型与日本农村地区老年和年轻男性酒精敏感性、饮酒行为及问题饮酒之间的关系。
研究对象为718名年龄63.3±10.8（均值±标准差）的日本男性，分为老年组（≥65岁，n = 357）和年轻组（<65岁，n = 361）。使用Bonferroni校正的χ(2)检验和调整年龄、体重指数及生活方式因素的多因素逻辑回归分析，比较各基因型之间的面部潮红频率、饮酒行为及CAGE阳性结果。
老年组中，ADH1B*1/2携带者“总是”面部潮红的频率显著低于ADH1B2/2携带者（P < 0.01）。老年组中，ADH1B1/2携带者的酒精摄入量（单位/天）相较于ADH1B2/2携带者有更高的趋势（P = 0.050）。在年轻组中，ADH1B各基因型之间在酒精敏感性和饮酒习惯方面通常未发现显著差异。ADH1B1/*1基因型在老年组中与问题饮酒呈正相关趋势（P = 0.080），但在年轻组中并非如此。ALDH2基因型在年轻组和老年组中均持续且强烈地影响酒精敏感性、饮酒行为及问题饮酒。
我们首次观察到65岁及以上老年男性中，ADH1B*1/2和ADH1B2/*2在酒精敏感性上存在显著差异。
