精氨酸-苯丙氨酸-酰胺相关肽在哺乳动物生殖中的作用。
The Role of Arginine-Phenylalanine-Amide-Related Peptides in Mammalian Reproduction.
作者信息
Salehi Mohammad Saied, Tamadon Amin, Jafarzadeh Shirazi Mohammad Reza, Namavar Mohammad Reza, Zamiri Mohammad Javad
机构信息
Department of Animal Science, College of Agriculture, Shiraz University, Shiraz, Iran.
Transgenic Technology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
出版信息
Int J Fertil Steril. 2015 Oct-Dec;9(3):268-76. doi: 10.22074/ijfs.2015.4540. Epub 2015 Oct 31.
Abstract
Until 2000 it was believed that gonadotropin-releasing hormone (GnRH) was the sole regulator of hypophyseal gonadotropes. In 2000, the discovery of a gonadotropin inhibitory hormone (GnIH) initiated a revolution in the field of reproductive physiology. Identification of GnIH homologues in mammals, the arginine-phenylalanine-amide (RFamide)-related peptides (RFRPs), indicated a similar function. Subsequently, further works conducted in various laboratories worldwide have shown that these neuropeptides inhibit the hypothalamic-hypophyseal axis. This review discusses the role of RFRPs in mammalian reproductive processes.
摘要
直到2000年，人们一直认为促性腺激素释放激素（GnRH）是垂体促性腺细胞的唯一调节因子。2000年，促性腺激素抑制激素（GnIH）的发现引发了生殖生理学领域的一场革命。在哺乳动物中鉴定出GnIH的同源物，即精氨酸-苯丙氨酸-酰胺（RFamide）相关肽（RFRP），表明它们具有相似的功能。随后，世界各地不同实验室开展的进一步研究表明，这些神经肽会抑制下丘脑-垂体轴。本文综述了RFRP在哺乳动物生殖过程中的作用。
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2
The hormonal control of ejaculation.
Nat Rev Urol. 2012 Sep;9(9):508-19. doi: 10.1038/nrurol.2012.147. Epub 2012 Aug 7.
3
RFamide-related peptide-3 receptor gene expression in GnRH and kisspeptin neurons and GnRH-dependent mechanism of action.
Endocrinology. 2012 Aug;153(8):3770-9. doi: 10.1210/en.2012-1133. Epub 2012 Jun 12.
4
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Endocrinology. 2012 Jul;153(7):3435-45. doi: 10.1210/en.2012-1066. Epub 2012 Jun 12.
5
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J Neuroendocrinol. 2012 May;24(5):725-36. doi: 10.1111/j.1365-2826.2012.02283.x.
8
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9
Identification, expression, and physiological functions of Siberian hamster gonadotropin-inhibitory hormone.
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