性早熟与精氨酸-苯丙氨酸-酰胺相关肽在下丘脑的表达有关吗？
Is precocious puberty linked to hypothalamic expression of arginine-phenylalanine-amide-related peptide?
作者信息
He Yuanyuan, Sun Wen, Yu Jian
机构信息
Department of Traditional Chinese Medicine, Children's Hospital of Fudan University, Shanghai, 200032, China.
出版信息
Iran J Basic Med Sci. 2017 Oct;20(10):1074-1078. doi: 10.22038/IJBMS.2017.9397.
Abstract
The up-regulation and down-regulation of gonadotropin-releasing hormone (GnRH) in central precocious puberty is not yet known. However, recent advances in neuroendocrinology have shown the controlling role of arginine-phenylalanine RF-amide-related peptides (RFRPs) on GnRH secretion in different phenomenon of reproduction such as estrus cycle and pregnancy, but the exact role of RFRPs in puberty and its related pathologic condition, precocious puberty, is not clear yet. This paper hypothesizes that RFRP is a regulatory peptide of puberty and might prevent the precocious puberty. On the basis of previous studies on hormonal fluctuations at the time of puberty, RFRP might have a role on controlling of premature secretion of GnRH and avoiding central precocious puberty.
摘要
中枢性性早熟中促性腺激素释放激素（GnRH）的上调和下调情况尚不清楚。然而，神经内分泌学的最新进展表明，精氨酸 - 苯丙氨酸RF - 酰胺相关肽（RFRPs）在发情周期和妊娠等不同生殖现象中对GnRH分泌具有控制作用，但RFRPs在青春期及其相关病理状况（性早熟）中的具体作用尚不清楚。本文推测RFRP是青春期的一种调节肽，可能预防性早熟。基于先前对青春期激素波动的研究，RFRP可能在控制GnRH过早分泌和避免中枢性性早熟方面发挥作用。
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