Sayama M, Mori M, Shirokawa T, Inoue M, Miyahara T, Kozuka H
Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, Japan.
Mutat Res. 1989 Jul;226(3):181-4. doi: 10.1016/0165-7992(89)90017-1.
The mutagenic activities of 2,6-dinitrotoluene (2,6-DNT) and its 6 metabolites, and their 8 related compounds were examined using Salmonella typhimurium strains TA98 and TA100 in the absence or presence of S9 mix. 2,6-DNT itself showed no mutagenicity toward either strain, but 2,6-dinitrobenzaldehyde (2,6-DNBAl), one of the metabolites of 2,6-DNT, showed the highest mutagenic activity in strain TA100. 2,6-DNBAl was a direct-acting mutagen, not requiring metabolic activation. The other compounds containing nitro groups showed weak or no mutagenic activity. This result suggests that the direct-acting mutagenicity of 2,6-DNBAl is mainly due to the aldehyde group of the 2,6-DNBAl molecule.
