Mori M A, Miyahara T, Taniguchi K, Hasegawa K, Kozuka H, Miyagoshi M, Nagayama T
Toxicol Lett. 1982 Sep;13(1-2):1-5. doi: 10.1016/0378-4274(82)90130-8.
2,4-Dinitrotoluene (2,4-DNT) and its metabolites (2A4NT, 4A2NT, 2,4-DNB, 2A4NB, 4A2NB, 2,4-DAT, 2N4AAT, 2A4AAT, 2A4AABA and 2,4-DNBA), and 2,4-dinitrobenzaldehyde (2,4-DNA1), putative metabolite of 2,4-DNT, were tested for mutagenicity in Salmonella typhimurium strains TA98 and TA100. 2,4-DAT, 2N4AAT, 2A4AAT, 2A4AABA and 2,4-DNBA were inactive for strains TA98 and TA100. 2,4-DNT itself was only a weak mutagen. Two aminonitrotoluenes (2A4NT and 4A2NT), two aminonitrobenzyl alcohols (2A4NB and 4A2NB) and 2,4-dinitrobenzyl alcohol (2,4-DNB) were increasingly mutagenic in that order, in both strains, however, they were only weak or weak mutagens at mM concentrations. In contrast with these compounds, 2,4-DNA1 was mutagenic even at microM concentrations in both strains. These results suggest that a high mutagenicity of 2,4-DNA1 may be correlated to the carcinogenicity of 2,4-DNT.
对2,4 - 二硝基甲苯（2,4 - DNT）及其代谢产物（2A4NT、4A2NT、2,4 - DNB、2A4NB、4A2NB、2,4 - DAT、2N4AAT、2A4AAT、2A4AABA和2,4 - DNBA）以及2,4 - 二硝基苯甲醛（2,4 - DNA1，2,4 - DNT的推定代谢产物）进行了鼠伤寒沙门氏菌TA98和TA100菌株的致突变性测试。2,4 - DAT、2N4AAT、2A4AAT、2A4AABA和2,4 - DNBA对TA98和TA100菌株无活性。2,4 - DNT本身只是一种弱诱变剂。两种氨基硝基甲苯（2A4NT和4A2NT）、两种氨基硝基苄醇（2A4NB和4A2NB）以及2,4 - 二硝基苄醇（2,4 - DNB）的诱变性依次增强，不过在毫摩尔浓度下它们都只是弱诱变剂。与这些化合物不同，2,4 - DNA1在两种菌株中即使在微摩尔浓度下也具有诱变性。这些结果表明，2,4 - DNA1的高诱变性可能与2,4 - DNT的致癌性相关。
