Ismı Onur, Vayısoğlu Yusuf, Arpaci Rabia Bozdogan, Eti Can, Pütürgeli Tuğçe, Gorur Kemal, Ozcan Cengiz
1 Department of Otorhinolaryngology, 2 Department of Pathology, Faculty of Medicine, University of Mersin, Mersin, Turkey.
Gland Surg. 2015 Dec;4(6):567-71. doi: 10.3978/j.issn.2227-684X.2015.01.03.
Carcinoma ex pleomorphic adenoma (CEPA) is the malignant salivary gland tumor originating from primary (de novo) or recurrent pleomorphic adenoma. Although parotid gland is the most common site, it can also be seen in submandibular gland or minor salivary glands. It can be seen rarely in head and neck region, such as oral cavity, trachea, nasal cavity and lacrimal gland. Although pleomorphic adenoma cases originating from ectopic salivary gland tissue in the neck region are present in the English literature, there is no published pleomorphic adenoma ex carcinoma case. In this case report we presented a CEPA as a 7.5 cm long neck mass in a 72-year-old woman originating from the submandibular region apart from submandibular gland. Difficulties in diagnosis and way to appropriate treatment are discussed with current literature.
多形性腺瘤恶变（CEPA）是一种起源于原发性（新发）或复发性多形性腺瘤的恶性涎腺肿瘤。虽然腮腺是最常见的发病部位，但也可见于下颌下腺或小涎腺。在头颈部区域，如口腔、气管、鼻腔和泪腺，该病较为罕见。虽然英文文献中有起源于颈部异位涎腺组织的多形性腺瘤病例，但尚无多形性腺瘤恶变病例的报道。在本病例报告中，我们呈现了一例发生在一名72岁女性患者身上的CEPA，表现为一个长7.5厘米的颈部肿块，起源于下颌下区域，但并非下颌下腺。本文结合当前文献讨论了诊断难点及合适的治疗方法。
