Buva Kirti Balkrishna, Deshmukh Ajinkya Amritrao, Deshmukh Atul A
Assistant Professor, Department of Oral Pathology, Bharati Vidyapeeth Deemed University, Dental College and Hospital, Navi Mumbai, Maharashtra, India.
Post Graduate Student, Department of Oral Pathology, Bharati Vidyapeeth Deemed University, Dental College and Hospital, Pune, Maharashtra, India.
J Clin Diagn Res. 2017 May;11(5):ZD15-ZD17. doi: 10.7860/JCDR/2017/25533.9919. Epub 2017 May 1.
A 65-year-old female patient reported with a chief complaint of swelling in the left lower region of the jaw since two years. On clinical examination, the swelling was present on the mandibular left posterior region and measuring approximately 6.2 cm antero-posteriorly × 6.2 cm mediolaterally × 8.7 cm superioinferiorly. Initially, it was non tender but eventually it became tender. Fine needle aspiration was done to rule out any salivary gland pathology and report obtained was carcinoma ex pleomorphic adenoma. Then, excisional biopsy was taken and tissue sent for histopathology. Histopathological diagnosis was benign adenoma with carcinoma. Later serial sections of tissue were studied and came to the conclusion of carcinoma ex pleomorphic adenoma which was non invasive type and showed bizarre cells with neoplastic changes. Benign part was composed of myxomatous area with partial capsule. Neoplastic cells showed invasion into capsule and few necrotic areas were also present. Overall interpretation was favoured Non invasive carcinoma ex pleomorphic adenoma. So here, we reported a case of Carcinoma ex Pleomorphic Adenoma (CAEXPA) which is a deadly and rare variant of salivary gland malignancy.
一名65岁女性患者主诉下颌左下部肿胀已有两年。临床检查发现，肿胀位于下颌左侧后部，前后径约6.2厘米，内外径约6.2厘米，上下径约8.7厘米。起初，它不压痛，但最终变得压痛。进行了细针穿刺以排除任何唾液腺病变，得到的报告是多形性腺瘤癌变。然后，进行了切除活检，并将组织送去做组织病理学检查。组织病理学诊断为良性腺瘤伴癌。后来对组织连续切片进行研究，得出多形性腺瘤癌变的结论，这是一种非侵袭性类型，显示出具有肿瘤性变化的奇异细胞。良性部分由有部分包膜的黏液瘤区域组成。肿瘤细胞显示侵入包膜，也存在一些坏死区域。总体诊断倾向于非侵袭性多形性腺瘤癌变。因此，我们在此报告一例多形性腺瘤癌变（CAEXPA），它是唾液腺恶性肿瘤中一种致命且罕见的变体。
