Li Lin, Li Chengyan, Pan Ping, Chen Xiaoli, Wu Xiaoke, Ng Ernest Hung Yu, Yang Dongzi
Department of Obstetrics and Gynecology, Sun Yat-sen Memorial Hospital, Guangzhou, China.
Department of Obstetric and Gynecology, Affiliated Hospital of Guangdong Medical College, Zhanjiang, China.
PLoS One. 2015 Dec 8;10(12):e0144072. doi: 10.1371/journal.pone.0144072. eCollection 2015.
To evaluate the effects of berberine on the menstrual pattern, ovulation rate, hormonal and metabolic profiles in anovulatory Chinese women with polycystic ovary syndrome.
Berberine 0.4 g three times per day was given for four months to 102 anovulatory Chinese women with polycystic ovary syndrome. The menstrual pattern, ovulation rate, hormonal and metabolic profiles were compared before and after the berberine treatment. Ovulation was confirmed by serum progesterone level ≥10 ng/ml.
A total of 98 of 102 subjects (96.1%) completed the four month treatment, including 69 (70.4%, 69/98) normal weight and 29 (29.6%, 29/98) overweight/obese. Fourteen women (14.3%, 14/98) had regained regular menses after berberine treatment and there was no significant difference between normal weight and overweight/obese groups. The ovulation rate was 25.0% over four months in the whole group, 22.5% in the normal weight group and 31.0% in the overweight/obese group. Sex hormone binding globulin, insulin resistance, total cholesterol, total triglyceride and low-density lipoprotein cholesterol decreased after berberine treatment in the normal weight group only.
Our study found that administration of berberine alone may improve the menstrual pattern and ovulation rate in anovulatory Chinese women with polycystic ovary syndrome. Berberine can also decrease sex hormone binding globulin, insulin resistance, total cholesterol, triglycerides and low-density lipoprotein cholesterol in normal weight polycystic ovary syndrome women.
Chictr.org ChiCTR-OO-13003943.
评估黄连素对无排卵型多囊卵巢综合征中国女性月经模式、排卵率、激素及代谢指标的影响。
102例无排卵型多囊卵巢综合征中国女性接受黄连素治疗，每日3次，每次0.4g，共4个月。比较黄连素治疗前后的月经模式、排卵率、激素及代谢指标。血清孕酮水平≥10ng/ml则证实排卵。
102例受试者中共有98例（96.1%）完成了4个月的治疗，其中69例（70.4%，69/98）体重正常，29例（29.6%，29/98）超重/肥胖。14例女性（14.3%，14/98）在黄连素治疗后恢复了规律月经，体重正常组和超重/肥胖组之间无显著差异。全组4个月的排卵率为25.0%，体重正常组为22.5%，超重/肥胖组为31.0%。仅体重正常组在黄连素治疗后性激素结合球蛋白、胰岛素抵抗、总胆固醇、总甘油三酯和低密度脂蛋白胆固醇有所下降。
我们的研究发现，单独使用黄连素可能改善无排卵型多囊卵巢综合征中国女性的月经模式和排卵率。黄连素还可降低体重正常的多囊卵巢综合征女性的性激素结合球蛋白、胰岛素抵抗、总胆固醇、甘油三酯和低密度脂蛋白胆固醇。
Chictr.org ChiCTR-OO-13003943
