Ciebiera Michał, Ali Mohamed, Prince Lillian, Jackson-Bey Tia, Atabiekov Ihor, Zgliczyński Stanisław, Al-Hendy Ayman
Second Department of Obstetrics and Gynecology, The Center of Postgraduate Medical Education, 01-809 Warsaw, Poland.
Department of Surgery, University of Illinois at Chicago, Chicago, IL 60612, USA.
J Clin Med. 2020 May 14;9(5):1479. doi: 10.3390/jcm9051479.
Uterine fibroids (UFs) remain a significant health issue for many women, with a disproportionate impact on women of color, likely due to both genetic and environmental factors. The prevalence of UFs is estimated to be approximately 70% depending on population. UF-derived clinical symptoms include pelvic pain, excessive uterine bleeding, gastrointestinal and voiding problems, as well as impaired fertility. Nowadays numerous methods of UF treatment are available-from conservative treatment to invasive surgeries. Selecting an appropriate treatment option should be individualized and adjusted to the patient's expectations as much as possible. So far, the mainstay of treatment is surgery, but their negative impact of future fertility is clear. On the other hand, emerging new pharmaceutical options have significant adverse effects like liver function impairment, hot flashes, bone density loss, endometrial changes, and inability to attempt conception during treatment. Several natural compounds are found to help treat UFs and relieve their symptoms. In this review we summarize all the current available data about natural compounds that may be beneficial for patients with UFs, especially those who want to preserve their future fertility or have treatment while actively pursuing conception. Vitamin D, epigallocatechin gallate, berberine, curcumin, and others are being used as alternative UF treatments. Moreover, we propose the concept of using combined therapies of natural compounds on their own or combined with hormonal agents to manage UFs. There is a strong need for more human clinical trials involving these compounds before promoting widespread usage.
子宫肌瘤（UFs）仍然是许多女性面临的重大健康问题，对有色人种女性的影响尤为严重，这可能是由遗传和环境因素共同导致的。根据人群不同，UFs的患病率估计约为70%。UFs引发的临床症状包括盆腔疼痛、子宫出血过多、胃肠道和排尿问题以及生育能力受损。如今，有许多治疗UFs的方法——从保守治疗到侵入性手术。选择合适的治疗方案应因人而异，并尽可能根据患者的期望进行调整。到目前为止，治疗的主要手段是手术，但其对未来生育能力的负面影响是显而易见的。另一方面，新出现的药物治疗方案有显著的副作用，如肝功能损害、潮热、骨密度降低、子宫内膜变化以及治疗期间无法尝试受孕。人们发现几种天然化合物有助于治疗UFs并缓解其症状。在这篇综述中，我们总结了目前所有关于可能对UFs患者有益的天然化合物的可用数据，特别是那些希望保留未来生育能力或在积极备孕时接受治疗的患者。维生素D、表没食子儿茶素没食子酸酯、黄连素、姜黄素等正被用作UFs的替代治疗方法。此外，我们提出了单独使用天然化合物或与激素药物联合使用来治疗UFs的概念。在推广广泛使用之前，迫切需要更多涉及这些化合物的人体临床试验。
