Mudakanagoudar Mahantesh S, Santhosh M C B
Departamento de Anestesiologia, Faculdade de Ciências Médicas e Hospital Shri Dharmasthala Manjunatheshwara, Karnataka, India.
Departamento de Anestesiologia, Faculdade de Ciências Médicas e Hospital Shri Dharmasthala Manjunatheshwara, Karnataka, India.
Rev Bras Anestesiol. 2016 Jan-Feb;66(1):24-8. doi: 10.1016/j.bjan.2014.07.012. Epub 2015 Nov 29.
Sevoflurane is an inhalational agent of choice in paediatric anaesthesia. For management of airways in children a suitable alternative to ETT is a paediatric proseal laryngeal mask airway (benchmark second generation SAD). Various studies have shown that less sevoflurane concentration is required for LMA insertion in comparison to TI. BIS is a useful monitor of depth of anaesthesia.
To compare concentration of sevoflurane (end tidal and MAC value) required for proseal laryngeal mask airway insertion and tracheal intubation in correlation with BIS index.
The prospective randomised single blind study was done in children between 2 and 9 years of ASA I and II and they were randomly allocated to Group P (proseal laryngeal mask airway insertion) and Group TI (tracheal intubation). No sedative premedication was given. Induction was done with 8% sevoflurane and then predetermined concentration was maintained for 10min. Airway was secured either by proseal laryngeal mask airway or endotracheal tube without using muscle relaxant. End tidal sevoflurane concentration, MAC, BIS, and other vital parameters were monitored every minute till insertion of an airway device. Insertion conditions were observed. Statistical analysis was done by Anova and Student's t test.
Difference between ETLMI (2.49±0.44) and ETTI (2.81±0.65) as well as MACLMI (1.67±0.13) and MACTI (1.77±0.43) was statistically very significant, while BISLMI (49.05±10.76) and BISTI (41.25±3.25) was significant. Insertion conditions were comparable in both the groups.
We can conclude that in children airway can be secured safely with proseal laryngeal mask airway using less sevoflurane concentration in comparison to tracheal intubation and this was supported by BIS index.
七氟醚是小儿麻醉中首选的吸入麻醉剂。对于儿童气道管理,小儿双管喉罩气道(第二代标准声门上气道装置)是气管内插管(ETT)的合适替代方案。多项研究表明,与气管内插管相比,插入喉罩气道所需的七氟醚浓度更低。脑电双频指数(BIS)是一种有用的麻醉深度监测指标。
比较插入双管喉罩气道和气管内插管所需的七氟醚浓度(呼气末浓度和最低肺泡有效浓度值),并与BIS指数进行相关性分析。
对年龄在2至9岁、美国麻醉医师协会(ASA)分级为I级和II级的儿童进行前瞻性随机单盲研究,将他们随机分为P组(插入双管喉罩气道)和TI组(气管内插管)。未给予镇静前用药。采用8%七氟醚诱导,然后维持预定浓度10分钟。在不使用肌肉松弛剂的情况下,通过双管喉罩气道或气管内导管确保气道安全。在插入气道装置前,每分钟监测呼气末七氟醚浓度、最低肺泡有效浓度、BIS及其他重要参数。观察插入条件。采用方差分析和学生t检验进行统计分析。
双管喉罩气道插入时的呼气末七氟醚浓度(ETLMI,2.49±0.44)与气管内插管时的呼气末七氟醚浓度(ETTI,2.81±0.65)之间以及双管喉罩气道插入时的最低肺泡有效浓度(MACLMI,1.67±0.13)与气管内插管时的最低肺泡有效浓度(MACTI,1.77±0.43)之间的差异具有统计学意义,而双管喉罩气道插入时的BIS(BISLMI,49.05±10.76)与气管内插管时的BIS(BISTI,41.25±3.25)之间的差异具有显著性。两组的插入条件相当。
我们可以得出结论,与气管内插管相比,在儿童中使用双管喉罩气道可在较低的七氟醚浓度下安全确保气道安全,这得到了BIS指数的支持。