反苯环丙胺治疗对环类抗抑郁药耐药的抑郁症

Tranylcypromine in depression resistant to cyclic antidepressions.

Nolen W A

Department of Biological Psychiatry, Psychiatric Centre Bloemendaal, The Hague, The Netherlands.

Prog Neuropsychopharmacol Biol Psychiatry. 1989;13(1-2):155-8. doi: 10.1016/0278-5846(89)90012-2.

Abstract

Non-responders to cyclic antidepressants were treated with the MAO-inhibitor tranylcypromine in two studies: the first study in an open comparison with L-5-hydroxytryptophan (L-5HTP), the second study in a double blind comparison with nomifensine. 2. While both L-5HTP and nomifensine appeared to be ineffective, tranylcypromine was effective in 26 out of 45 patients. 3. It is concluded that besides ECT also MAO-inhibitors such as tranylcypromine are an effective alternative for depressed patients not responding to cyclic antidepressants.

摘要

在两项研究中，对环类抗抑郁药无反应者接受了单胺氧化酶抑制剂反苯环丙胺治疗：第一项研究是与L-5-羟色氨酸（L-5HTP）进行开放对比，第二项研究是与诺米芬辛进行双盲对比。2. 虽然L-5HTP和诺米芬辛似乎均无效，但反苯环丙胺在45名患者中有26名有效。3. 得出的结论是，除电休克疗法外，像反苯环丙胺这样的单胺氧化酶抑制剂也是对环类抗抑郁药无反应的抑郁症患者的一种有效替代疗法。