Molinas F C, de Bracco M M, Maiztegui J I
Instituto de Investigaciones Médicas Alfredo Lanari, Faculty of Medicine, University of Buenos Aires, Argentina.
Rev Infect Dis. 1989 May-Jun;11 Suppl 4:S762-70. doi: 10.1093/clinids/11.supplement_4.s762.
The salient abnormalities of blood coagulation found in the acute phase of Argentine hemorrhagic fever (AHF) were thrombocytopenia, prolonged partial thromboplastin time activated with kaolin, low factor VIII:C activity concurrent with high levels of von Willebrand factor, and increased values of factor V. No evidence of disseminated intravascular coagulation (DIC) was observed. Therefore, the hemostatic abnormalities detected in patients with AHF could not be attributed to DIC. There was no correlation between severity of the disease and occurrence of impairment of coagulation. Complement activation was observed during the acute phase of AHF. There was reduction of total complement and C2 activity. Antigenic levels of C1q, C3, and C5 were low; level of C4 antigen was high. Degradation products of C3 and B were demonstrated before day 11. Experimental models of AHF were developed (guinea pigs, Callitrix jacchus). These models may be useful, but they reproduced only some of the features of blood coagulation and complement abnormalities described in human AHF.
在阿根廷出血热（AHF）急性期发现的血液凝固显著异常包括血小板减少、高岭土激活的部分凝血活酶时间延长、低因子VIII:C活性伴高水平血管性血友病因子，以及因子V值升高。未观察到弥散性血管内凝血（DIC）的证据。因此，AHF患者中检测到的止血异常不能归因于DIC。疾病严重程度与凝血功能损害的发生之间无相关性。在AHF急性期观察到补体激活。总补体和C2活性降低。C1q、C3和C5的抗原水平较低；C4抗原水平较高。在第11天之前检测到C3和B的降解产物。建立了AHF的实验模型（豚鼠、狨猴）。这些模型可能有用，但它们仅重现了人类AHF中描述的血液凝固和补体异常的部分特征。
