Levis S C, Saavedra M C, Ceccoli C, Feuillade M R, Enria D A, Maiztegui J I, Falcoff R
J Interferon Res. 1985 Summer;5(3):383-9. doi: 10.1089/jir.1985.5.383.
To explore the endogenous interferon levels in patients of Argentine hemorrhagic fever (AHF) with different clinical evolution of the disease, 29 fatal and 33 surviving cases of AHF were analyzed. As previously reported, the titers of endogenous alpha-IFN in patients with AHF are very high, generally between 2,000 and 64,000 IU/ml. Thus far, these are the highest levels of circulating interferon detected in any human viral disease. In this study it was found that during the second week of evolution the titers of interferon were significantly higher in fatal cases than in survivors. Therefore, very high levels of interferon have a prognostic value in AHF.
为探究阿根廷出血热（AHF）患者在疾病不同临床进展阶段的内源性干扰素水平，对29例AHF死亡病例和33例存活病例进行了分析。如先前报道，AHF患者体内内源性α-干扰素的滴度非常高，一般在2000至64000 IU/ml之间。迄今为止，这些是在任何人类病毒性疾病中检测到的循环干扰素的最高水平。在本研究中发现，在疾病进展的第二周，死亡病例的干扰素滴度显著高于存活者。因此，干扰素的高水平在AHF中具有预后价值。
