1 Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences , Tehran, Iran .
2 Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences , Tehran, Iran .
Thyroid. 2016 Mar;26(3):458-65. doi: 10.1089/thy.2015.0276. Epub 2016 Jan 21.
Current guidelines used for establishing reference intervals for thyroid peroxidase antibodies (TPOAb), recommended by the National Academy of Clinical Biochemistry, have been a matter of controversy. The present study sought to determine TPOAb reference intervals for different age and sex groups, as well as the TPOAb cutoff points for subclinical and overt hypothyroidism in an iodine-sufficient population.
This cross-sectional study was conducted within the framework of the prospective Tehran Thyroid Study (TTS), in which 4174 healthy euthyroid individuals were followed for 10 years. Thyroid function tests and TPOAb were assessed.
The mean age ± standard deviation of participants was 39.3 ± 15.2 years. Estimated reference intervals for TPOAb corresponding to the 2.5th and 97.5th percentiles were 1.5-32.8 and 2.1-35 IU/mL in males and females, respectively. There were no significant variations in the different age groups in either sex. The optimal cutoff points for TPOAb were 18.38 and 14.77 IU/mL for predicting clinical and subclinical hypothyroidism, respectively.
This study establishes the reference intervals and the optimal cutoff points for TPOAb in an iodine-sufficient population.
目前，国家临床生物化学学院推荐的甲状腺过氧化物酶抗体（TPOAb）参考区间一直存在争议。本研究旨在为不同年龄和性别组确定 TPOAb 参考区间，以及在碘充足人群中确定亚临床和显性甲状腺功能减退的 TPOAb 截断值。
这项横断面研究是在前瞻性德黑兰甲状腺研究（TTS）的框架内进行的，其中 4174 名健康的甲状腺功能正常者随访了 10 年。检测了甲状腺功能和 TPOAb。
参与者的平均年龄±标准差为 39.3±15.2 岁。男性和女性 TPOAb 的估计参考区间分别为第 2.5 百分位数和第 97.5 百分位数 1.5-32.8 和 2.1-35IU/ml。在任何性别中，不同年龄组之间均无明显变化。TPOAb 的最佳截断值分别为 18.38 和 14.77IU/ml，用于预测临床和亚临床甲状腺功能减退。
本研究在碘充足人群中建立了 TPOAb 的参考区间和最佳截断值。
