Ghazisaeidi Behnaz, Sarvghadi Farzaneh, Ghasemi Asghar, Tohidi Maryam, Azizi Fereidoun, Amouzegar Atieh
Endocrine Research Center, Research Institute for Endocrine Sciences, Ayatollah Taleghani Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
School of Medicine, Ayatollah Taleghani Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Int J Endocrinol Metab. 2021 Mar 28;19(3):e109214. doi: 10.5812/ijem.109214. eCollection 2021 Jul.
Nitric oxide (NO) plays a key role in thyroid function regulation through the inhibition of iodide (I) uptake at the thyroidal sodium-iodide symporter (NIS) and impacts on the thyroid vascularity and blood flow.
This study aimed to evaluate the association between serum NO metabolites (NOx) and thyroid-stimulating hormone (TSH), free thyroxin (FT4), and anti-thyroid peroxidase (TPOAb) changes. Also, it aimed at evaluating the correlation between serum NOx and the incidence of clinical hypothyroidism, characterized by elevated TSH level and decreased FT4 concentration, and subclinical hypothyroidism, characterized by mildly elevated TSH level despite FT4 concentration within the normal range, over three years of follow-up.
This study included 1,137 participants of the Tehran Thyroid study (TTS), aged > 20 years old, for whom data on serum TSH, FT4, and TPOAb in the third and fourth phases, and serum NOx in the third phase were available. Changes in TSH (ΔTSH), FT4 (ΔFT4), and TPOAb (ΔTPO) between the third and fourth phases were calculated, and the associations between serum NOx and ΔTSH, ΔFT4, and ΔTPOAb were assessed after multivariable adjustment using linear regression analysis.
No significant association was found between serum NOx and ΔTSH, ΔFT4, and ΔTPOAb after the multivariable adjustment; neither was any observed in TPOAb split groups after multivariable adjustment. No significant association was found between serum NOx tertiles and clinical and subclinical hypothyroidism incidence in the fourth phase of TTS.
There was no association between serum NOx levels and changes in TSH, FT4, and TPOAb and clinical and subclinical hypothyroidism incidence.
一氧化氮（NO）通过抑制甲状腺钠-碘同向转运体（NIS）对碘（I）的摄取，在甲状腺功能调节中发挥关键作用，并影响甲状腺血管和血流。
本研究旨在评估血清NO代谢产物（NOx）与促甲状腺激素（TSH）、游离甲状腺素（FT4）以及抗甲状腺过氧化物酶（TPOAb）变化之间的关联。此外，本研究旨在评估在三年随访期间，血清NOx与以TSH水平升高和FT4浓度降低为特征的临床甲状腺功能减退症以及以TSH水平轻度升高但FT4浓度在正常范围内为特征的亚临床甲状腺功能减退症发病率之间的相关性。
本研究纳入了德黑兰甲状腺研究（TTS）中1137名年龄大于20岁的参与者，这些参与者可获取第三阶段和第四阶段血清TSH、FT4和TPOAb的数据以及第三阶段血清NOx的数据。计算第三阶段和第四阶段之间TSH（ΔTSH）、FT4（ΔFT4）和TPOAb（ΔTPO）的变化，并在多变量调整后使用线性回归分析评估血清NOx与ΔTSH、ΔFT4和ΔTPOAb之间的关联。
多变量调整后，未发现血清NOx与ΔTSH、ΔFT4和ΔTPOAb之间存在显著关联；多变量调整后的TPOAb分组中也未观察到任何显著关联。在TTS第四阶段，未发现血清NOx三分位数与临床和亚临床甲状腺功能减退症发病率之间存在显著关联。
血清NOx水平与TSH、FT4和TPOAb的变化以及临床和亚临床甲状腺功能减退症发病率之间无关联。
