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《2015/16 药理学简明指南:电压门控离子通道》

The Concise Guide to PHARMACOLOGY 2015/16: Voltage-gated ion channels.

作者信息

Alexander Stephen Ph, Catterall William A, Kelly Eamonn, Marrion Neil, Peters John A, Benson Helen E, Faccenda Elena, Pawson Adam J, Sharman Joanna L, Southan Christopher, Davies Jamie A

机构信息

School of Biomedical Sciences, University of Nottingham Medical School, Nottingham, NG7 2UH, UK.

Department of Pharmacology, University of Washington, Seattle, 98195-7280, WA, USA.

出版信息

Br J Pharmacol. 2015 Dec;172(24):5904-41. doi: 10.1111/bph.13349.

DOI:10.1111/bph.13349
PMID:26650441
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4718209/
Abstract

The Concise Guide to PHARMACOLOGY 2015/16 provides concise overviews of the key properties of over 1750 human drug targets with their pharmacology, plus links to an open access knowledgebase of drug targets and their ligands (www.guidetopharmacology.org), which provides more detailed views of target and ligand properties. The full contents can be found at http://onlinelibrary.wiley.com/doi/10.1111/bph.13350/full. Voltage-gated ion channels are one of the eight major pharmacological targets into which the Guide is divided, with the others being: G protein-coupled receptors, ligand-gated ion channels, other ion channels, nuclear hormone receptors, catalytic receptors, enzymes and transporters. These are presented with nomenclature guidance and summary information on the best available pharmacological tools, alongside key references and suggestions for further reading. The Concise Guide is published in landscape format in order to facilitate comparison of related targets. It is a condensed version of material contemporary to late 2015, which is presented in greater detail and constantly updated on the website www.guidetopharmacology.org, superseding data presented in the previous Guides to Receptors & Channels and the Concise Guide to PHARMACOLOGY 2013/14. It is produced in conjunction with NC-IUPHAR and provides the official IUPHAR classification and nomenclature for human drug targets, where appropriate. It consolidates information previously curated and displayed separately in IUPHAR-DB and GRAC and provides a permanent, citable, point-in-time record that will survive database updates.

摘要

《2015/16药理学简明指南》简要概述了1750多种人类药物靶点的关键特性及其药理学,还提供了药物靶点及其配体开放获取知识库(www.guidetopharmacology.org)的链接,该知识库能提供靶点和配体特性的更详细信息。完整内容可在http://onlinelibrary.wiley.com/doi/10.1111/bph.13350/full上查阅。电压门控离子通道是该指南划分的八大主要药理学靶点之一,其他靶点包括:G蛋白偶联受体、配体门控离子通道、其他离子通道、核激素受体、催化受体、酶和转运体。书中给出了命名指南以及关于最佳可用药理学工具的总结信息,同时列出了关键参考文献和进一步阅读建议。《简明指南》采用横向排版以便于比较相关靶点。它是2015年末当代资料的精简版,在网站www.guidetopharmacology.org上有更详细的呈现且不断更新,取代了之前的《受体与通道指南》及《2013/14药理学简明指南》中的数据。它是与NC - IUPHAR联合制作的,在适当的地方提供人类药物靶点的官方IUPHAR分类和命名。它整合了先前在IUPHAR - DB和GRAC中分别整理和展示的信息,并提供了一份永久性的、可引用的、特定时间点的记录,该记录在数据库更新后仍将存在。