He Li-Ying, Hu Mei-Bian, Li Ruo-Lan, Zhao Rong, Fan Lin-Hong, He Lin, Lu Feng, Ye Xun, Huang Yong-Liang, Wu Chun-Jie
College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Institute of Pharmaceutical and Food engineering, Shanxi University of Chinese Medicine, Jinzhong, China.
Front Pharmacol. 2021 Mar 4;12:604040. doi: 10.3389/fphar.2021.604040. eCollection 2021.
Epilepsy is a chronic disease that can cause temporary brain dysfunction as a result of sudden abnormal discharge of the brain neurons. The seizure mechanism of epilepsy is closely related to the neurotransmitter imbalance, synaptic recombination, and glial cell proliferation. In addition, epileptic seizures can lead to mitochondrial damage, oxidative stress, and the disorder of sugar degradation. Although the mechanism of epilepsy research has reached up to the genetic level, the presently available treatment and recovery records of epilepsy does not seem promising. Recently, natural medicines have attracted more researches owing to their low toxicity and side-effects as well as the excellent efficacy, especially in chronic diseases. In this study, the antiepileptic mechanism of the bioactive components of natural drugs was reviewed so as to provide a reference for the development of potential antiepileptic drugs. Based on the different treatment mechanisms of natural drugs considered in this review, it is possible to select drugs clinically. Improving the accuracy of medication and the cure rate is expected to compensate for the shortage of the conventional epilepsy treatment drugs.
癫痫是一种慢性疾病，可因脑神经元突然异常放电而导致暂时性脑功能障碍。癫痫的发作机制与神经递质失衡、突触重组及胶质细胞增殖密切相关。此外，癫痫发作可导致线粒体损伤、氧化应激及糖代谢紊乱。尽管癫痫的研究机制已达到基因水平，但目前可用的癫痫治疗及康复记录似乎并不乐观。近年来，天然药物因其低毒性、副作用及卓越疗效，尤其是在慢性病治疗方面，吸引了更多研究。本研究综述了天然药物生物活性成分的抗癫痫机制，为潜在抗癫痫药物的开发提供参考。基于本综述中考虑的天然药物不同治疗机制，临床上有可能选择药物。提高用药准确性及治愈率有望弥补传统癫痫治疗药物的不足。
