通过光刻法制备聚合物微针阵列
Polymeric Microneedle Array Fabrication by Photolithography.
作者信息
Kathuria Himanshu, Kochhar Jaspreet Singh, Fong Michelle Hui Min, Hashimoto Michinao, Iliescu Ciprian, Yu Hanry, Kang Lifeng
机构信息
Department of Pharmacy, National University of Singapore.
Singapore University of Technology and Design.
出版信息
J Vis Exp. 2015 Nov 17(105):52914. doi: 10.3791/52914.
Abstract
This manuscript describes the fabrication of polymeric microneedle (MN) arrays by photolithography. It involves a simple mold-free process by using a photomask consisting of embedded micro-lenses. Embedded micro-lenses were found to influence MN geometry (sharpness). Robust MN arrays with tip diameters ranging between 41.5 µm ± 8.4 µm and 71.6 µm ± 13.7 µm, with two different lengths (1,336 µm ± 193 µm and 957 µm ± 171 µm) were fabricated. These MN arrays may provide potential applications in delivery of low molecular and macromolecular therapeutic agents through skin.
摘要
本手稿描述了通过光刻法制造聚合物微针（MN）阵列的过程。它涉及一种简单的无模具工艺，使用由嵌入式微透镜组成的光掩模。发现嵌入式微透镜会影响微针的几何形状（尖锐度）。制造出了尖端直径在41.5 µm ± 8.4 µm至71.6 µm ± 13.7 µm之间、具有两种不同长度（1,336 µm ± 193 µm和957 µm ± 171 µm）的坚固微针阵列。这些微针阵列可能在通过皮肤递送低分子和大分子治疗剂方面具有潜在应用。
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