Dardano Principia, Caliò Alessandro, Di Palma Vincenza, Bevilacqua Maria Fortuna, Di Matteo Andrea, De Stefano Luca
Institute for Microelectronics and Microsystems, National Council of Research, Via Pietro Castellino 111, Napoli 80131, Italy.
IMAST Scarl, Piazza Bovio 22, Naples 80133, Italy.
Materials (Basel). 2015 Dec 11;8(12):8661-8673. doi: 10.3390/ma8125484.
In this work, two procedures for fabrication of polymeric microneedles based on direct photolithography, without any etching or molding process, are reported. Polyethylene glycol (average molecular weight 250 Da), casted into a silicone vessel and exposed to ultraviolet light (365 nm) through a mask, cross-links when added by a commercial photocatalyzer. By changing the position of the microneedles support with respect to the vessel, different shapes and lengths can be achieved. Microneedles from a hundred microns up to two millimeters have been obtained just tuning the radiation dose, by changing the exposure time (5-15 s) and/or the power density (9-18 mW/cm²) during photolithography. Different microneedle shapes, such as cylindrical, conic or lancet-like, for specific applications such as micro-indentation or drug delivery, are demonstrated.
在这项工作中，报道了两种基于直接光刻技术制造聚合物微针的方法，无需任何蚀刻或成型工艺。将聚乙二醇（平均分子量250 Da）浇铸到硅树脂容器中，并通过掩膜暴露于紫外光（365 nm）下，添加商用光催化剂后会发生交联。通过改变微针支架相对于容器的位置，可以实现不同的形状和长度。通过在光刻过程中改变曝光时间（5 - 15秒）和/或功率密度（9 - 18 mW/cm²）来调整辐射剂量，已获得了从一百微米到两毫米的微针。展示了用于微压痕或药物递送等特定应用的不同微针形状，如圆柱形、圆锥形或柳叶刀形。
