School of Biomedical Sciences & Pharmacy, Faculty of Health & Medicine, University of Newcastle, Callaghan, NSW 2308, Australia.
Nanomedicine (Lond). 2016 Jan;11(1):63-79. doi: 10.2217/nnm.15.186. Epub 2015 Dec 11.
The use of nanotechnology has great potentials to revolutionize the future cancer diagnosis and therapy. In this context, various nanoparticles (NPs) have been developed for targeted delivery of diagnostic/therapeutic agents to the tumor sites, which thus result in greater efficacy and much less side effects. The targeting property of NPs is often achieved by functionalizing their surface with tumor-specific ligands, such as antibodies, peptides, small molecules and oligonucleotides. In this review, we will discuss recent progress in the multifunctional design of antibody-targeted NPs with a special focus on liposomal, polymeric and protein-based delivery systems.
纳米技术的应用具有极大的潜力，可以彻底改变未来癌症的诊断和治疗方式。在这种情况下，已经开发出各种纳米粒子 (NP) 来将诊断/治疗剂靶向递送至肿瘤部位，从而提高疗效并大大减少副作用。NP 的靶向特性通常通过用肿瘤特异性配体（如抗体、肽、小分子和寡核苷酸）对其表面进行功能化来实现。在本综述中，我们将讨论具有抗体靶向的多功能纳米粒子的最新进展，特别关注脂质体、聚合物和基于蛋白质的递药系统。
