Muthu Madaswamy S, Singh Sanjay
Department of Pharmacology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India.
Nanomedicine (Lond). 2009 Jan;4(1):105-18. doi: 10.2217/17435889.4.1.105.
Novel technology in the nanomedicine field is expected to develop innovative products as targeted drug-delivery approaches. Targeted drug delivery of various drugs for the treatment of cancer, AIDS and brain disorders is the primary research area in which nanomedicines have a major role and need. This review is concerned with emerging targeted nanomedicines (polymeric nanoparticles, solid lipid nanoparticles, polymeric micelles, dendrimers, liposomes, gold nanoparticles and magnetic nanoparticles) and multifunctional carriers capable of combining targeted drug delivery and imaging (polymeric micelles, dendrimers and magnetic nanoparticles) in the field of pharmaceutical applications. The significant toxicity issues associated with these nanomedicines are also explored here.
纳米医学领域的新技术有望开发出创新产品，作为靶向给药方法。针对癌症、艾滋病和脑部疾病治疗的各种药物的靶向给药是纳米医学发挥主要作用且有需求的主要研究领域。本综述关注药物应用领域中新兴的靶向纳米药物（聚合物纳米颗粒、固体脂质纳米颗粒、聚合物胶束、树枝状大分子、脂质体、金纳米颗粒和磁性纳米颗粒）以及能够将靶向给药与成像相结合的多功能载体（聚合物胶束、树枝状大分子和磁性纳米颗粒）。本文还探讨了与这些纳米药物相关的重大毒性问题。
