去甲肾上腺素在发育过程中依赖经验的可塑性中的神经调节作用。
Neuromodulatory influence of norepinephrine during developmental experience-dependent plasticity.
作者信息
Golovin Randall M, Ward Nicholas J
机构信息
Neuroscience Graduate Program, Vanderbilt University, Nashville, Tennessee; Vanderbilt Brain Institute, Vanderbilt University, Nashville, Tennessee;
Vanderbilt Brain Institute, Vanderbilt University, Nashville, Tennessee; Vanderbilt Vision Research Center, Vanderbilt University, Nashville, Tennessee; and Department of Psychology, Vanderbilt University, Nashville, Tennessee
出版信息
J Neurophysiol. 2016 Jul 1;116(1):1-4. doi: 10.1152/jn.00461.2015. Epub 2015 Dec 9.
Critical periods represent phases of development during which neuronal circuits and their responses can be readily shaped by stimuli. Experience-dependent plasticity that occurs within these critical periods can be influenced in many ways; however, Shepard et al. (J Neurosci 35: 2432-2437, 2015) recently singled out norepinephrine as an essential driver of this plasticity within the auditory cortex. This work provides novel insight into the mechanisms of critical period plasticity and challenges previous conceptions that a functional redundancy exists between noradrenergic and cholinergic influences on cortical plasticity.
关键期代表发育阶段，在此期间神经元回路及其反应能够轻易地由刺激塑造。在这些关键期内发生的依赖经验的可塑性可受到多种方式的影响；然而，谢泼德等人（《神经科学杂志》35: 2432 - 2437, 2015年）最近指出去甲肾上腺素是听觉皮层内这种可塑性的关键驱动因素。这项研究为关键期可塑性机制提供了新的见解，并挑战了之前关于去甲肾上腺素能和胆碱能对皮层可塑性的影响存在功能冗余的观念。
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