Burbank Brant D, Slater Michael, Kava Alyssa, Doyle James, McHale William A, Latta Mark A, Gross Stephen M
Department of Oral Biology, School of Dentistry, Creighton University, Omaha, NE 68178, United States.
Department of Chemistry, College of Arts and Sciences, Creighton University, Omaha, NE 68178, United States.
J Dent. 2016 Feb;45:32-8. doi: 10.1016/j.jdent.2015.11.009. Epub 2015 Dec 2.
Dental materials capable of releasing calcium, phosphate and fluoride are of great interest for remineralization. Microencapsulated aqueous solutions of these ions in orthodontic cement demonstrate slow, sustained release by passive diffusion through a permeable membrane without the need for dissolution or etching of fillers. The potential to charge a dental material formulated with microencapsulated water with fluoride by toothbrushing with over the counter toothpaste and the effect of microcapsules on cement adhesion to enamel was determined.
Orthodontic cements that contained microcapsules with water and controls without microcapsules were brushed with over-the-counter toothpaste and fluoride release was measured. Adhesion measurements were performed loading orthodontic brackets to failure. Cements that contained microencapsulated solutions of 5.0M Ca(NO3)2, 0.8M NaF, 6.0MK2HPO4 or a mixture of all three were prepared. Ion release profiles were measured as a function of time.
A greater fluoride charge and re-release from toothbrushing was demonstrated compared to a control with no microcapsules. Adhesion of an orthodontic cement that contained microencapsulated remineralizing agents was 8.5±2.5MPa compared to the control without microcapsules which was of 8.3±1.7MPa. Sustained release of fluoride, calcium and phosphate ions from cement formulated with microencapsulated remineralizing agents was demonstrated.
Orthodontic cements with microcapsules show a release of bioavailable fluoride, calcium, and phosphate ions near the tooth surface while having the ability to charge with fluoride and not effect the adhesion of the material to enamel. Incorporation of microcapsules in dental materials is promising for promoting remineralization.
能够释放钙、磷和氟的牙科材料对再矿化具有重要意义。将这些离子的微囊化水溶液添加到正畸粘固剂中，通过渗透膜被动扩散实现缓慢、持续释放，无需填料溶解或蚀刻。研究了用非处方牙膏刷牙给含微囊化水的牙科材料添加氟的可能性，以及微囊对粘固剂与牙釉质粘结的影响。
用非处方牙膏刷含微囊化水的正畸粘固剂和不含微囊的对照物，测量氟释放量。通过加载正畸托槽直至破坏进行粘结力测量。制备了含5.0M硝酸钙、0.8M氟化钠、6.0M磷酸氢二钾微囊化溶液或三者混合物的粘固剂。测量离子释放曲线随时间的变化。
与无微囊的对照物相比，刷牙后显示出更高的氟添加量和再释放量。含微囊化再矿化剂的正畸粘固剂的粘结力为8.5±2.5MPa，而不含微囊的对照物为8.3±1.7MPa。证明了含微囊化再矿化剂的粘固剂能持续释放氟、钙和磷酸根离子。
含微囊的正畸粘固剂在牙表面附近释放生物可利用性的氟、钙和磷酸根离子，同时具有添加氟的能力且不影响材料与牙釉质的粘结。在牙科材料中加入微囊对促进再矿化很有前景。
