Dodhia Hiten, Kun Liu, Logan Ellis Hugh, Crompton James, Wierzbicki Anthony S, Williams Helen, Hodgkinson Anna, Balazs John
Lambeth & Southwark Councils, Public Health, London, UK.
Division of Health and Social Care Research, King's College London, London, UK.
BMJ Open. 2015 Dec 9;5(12):e008678. doi: 10.1136/bmjopen-2015-008678.
To assess quality of management and determinants in lipid control for secondary prevention of cardiovascular disease (CVD) using multilevel regression models.
Cross-sectional study.
Inner London borough, with a primary care registered population of 378,000 (2013).
48/49 participating general practices with 7869 patients on heart disease/stroke registers were included.
(1) Recording of current total cholesterol levels and lipid control according to national evidence-based standards. (2) Assessment of quality by age, sex, ethnicity, deprivation, presence of other risks or comorbidity in meeting both lipid measurement and control standards.
Some process standards were not met. Patients with a current cholesterol measurement >5 mmol/L were less likely to have a current statin prescription (adjusted OR=3.10; 95% CI 2.70 to 3.56). They were more likely to have clustering of other CVD risk factors. Women were significantly more likely to have raised cholesterol after adjustment for other factors (adjusted OR=1.74; 95% CI 1.53 to 1.98).
In this study, the key factor that explained poor lipid control in people with CVD was having no current prescription record of a statin. Women were more likely to have poorly controlled cholesterol (independent of comorbid risk factors and after adjusting for age, ethnicity, deprivation index and practice-level variation). Women with CVD should be offered statin prescription and may require higher statin dosage for improved control.
使用多水平回归模型评估心血管疾病(CVD)二级预防中血脂控制的管理质量及决定因素。
横断面研究。
伦敦市中心行政区,2013年初级保健注册人口为378,000。
纳入了48/49家参与研究的全科诊所,这些诊所的心脏病/中风登记册上有7869名患者。
(1)根据国家循证标准记录当前总胆固醇水平和血脂控制情况。(2)根据年龄、性别、种族、贫困程度、是否存在其他风险因素或合并症来评估达到血脂测量和控制标准的质量。
一些流程标准未得到满足。当前胆固醇测量值>5 mmol/L的患者当前开具他汀类药物处方的可能性较小(调整后比值比=3.10;95%置信区间2.70至3.56)。他们更有可能存在其他CVD风险因素聚集的情况。在调整其他因素后,女性胆固醇升高的可能性显著更高(调整后比值比=1.74;95%置信区间1.53至1.98)。
在本研究中,CVD患者血脂控制不佳的关键因素是目前没有他汀类药物的处方记录。女性更有可能胆固醇控制不佳(独立于合并风险因素,且在调整年龄、种族、贫困指数和诊所层面差异后)。患有CVD的女性应开具他汀类药物处方,可能需要更高剂量的他汀类药物以改善控制效果。