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Serological Responses to a Norovirus Nonstructural Fusion Protein after Vaccination and Infection.

作者信息

Hesse Shayla, Neill Frederick H, Estes Mary K, Shanker Sreejesh, Prasad B V Venkataram, Ferreira Jennifer, Atmar Robert L

机构信息

Department of Medicine, Baylor College of Medicine, Houston, Texas, USA.

Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, USA.

出版信息

Clin Vaccine Immunol. 2015 Dec 9;23(2):181-3. doi: 10.1128/CVI.00595-15. Print 2016 Feb.

Abstract

The performance of an assay to detect antibodies to a norovirus nonstructural fusion protein, designated VPR and consisting of three proteins (GI.1 virus protein genome-linked [VPg], a virus protease, and an RNA-dependent RNA polymerase), was evaluated. The assay sensitivity and specificity were 74.5% and >95%, respectively, for identifying GI.1 norovirus infection among persons who received either a monovalent GI.1 norovirus virus-like particle (VLP) vaccine or placebo by the intranasal route followed by an oral live GI.1 norovirus challenge.

摘要

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