Altintas Ayse, Najar Bjar, Gozubatik-Celik Gokcen, Menku Sukriye F
Department of Neurology, Cerrahpasa Faculty of Medicine, Istanbul University, Istanbul, Turkey.
Eur Neurol. 2015;74(5-6):296-302. doi: 10.1159/000441450. Epub 2015 Dec 12.
To conduct the first retrospective clinical study investigating pregnancy in Turkish multiple sclerosis (MS) patients.
We evaluated 558 pregnancies in 199 MS patients and results were compared with general Turkish population's data. The fertility rate in the MS group was found to be lower than that in the general population, even before MS diagnosis was established. Our study suggests that the higher number of pregnancies may have a favorable effect on transition from relapsing-remitting MS to secondary progressive MS, although no effect has been shown regarding the possibility to reach EDSS 6.0 as a milestone.
Our data support the conclusion that MS does not have a negative effect on the MS course and disability.
开展第一项针对土耳其多发性硬化症（MS）患者妊娠情况的回顾性临床研究。
我们评估了199例MS患者的558次妊娠情况，并将结果与土耳其普通人群的数据进行了比较。发现MS组的生育率甚至在确诊MS之前就低于普通人群。我们的研究表明，较高的妊娠次数可能对复发缓解型MS向继发进展型MS的转变有有利影响，尽管对于达到扩展残疾状态量表（EDSS）6.0这一里程碑的可能性未显示有影响。
我们的数据支持以下结论，即MS对MS病程和残疾没有负面影响。
