磷酸甘油酸激酶1表达下调与胆囊癌患者预后不良相关。
Down-Regulated Phosphoglycerate Kinase 1 Expression Is Associated With Poor Prognosis in Patients With Gallbladder Cancer.
作者信息
Lu Wei, Gao Jian, Yang Jingyun, Cao Yang, Jiang Lin, Li Maolan, Zhang Yijian, Zhou Jian, Liu Yingbin
机构信息
From the General Surgery Department and Research Institute, Xinhua Hospital, Affiliated with School of Medicine, Shanghai Jiao Tong University, Shanghai, China (WL, YC, ML, YL); Center of Clinical Epidemiology and Evidence-Based Medicine, Fudan University, Shanghai, China (JG); Institute of Biliary Tract Diseases Research, School of Medicine (WL, YC, LJ, ML, YZ, JZ, YL) and Institute of Social Cognitive and Behavioral Sciences (WL), Shanghai Jiao Tong University, Shanghai, China; and Rush Alzheimer's Disease Center (JY) and Department of Neurological Sciences (JY), Rush University Medical Center, Chicago, IL.
出版信息
Medicine (Baltimore). 2015 Dec;94(49):e2244. doi: 10.1097/MD.0000000000002244.
To evaluate prognostic significance of phosphoglycerate kinase 1 (PGK1) protein expression in patients with gallbladder cancer (GBC).Ninety-five patients who underwent surgical resection for GBC between January 2004 and December 2010 were enrolled. Overall survival (OS) and disease-free survival (DFS) were evaluated over a 10-year follow-up. PGK1 expression was assessed by tissue microarray and immunohistochemistry. Prognostic significance was analyzed using multivariate Cox regression.PGK1 was highly expressed in all gallbladder mucosa. Decreased PGK1 expression was detected in 54.7% (52/95) of patients with GBC. It was significantly down-regulated in GBC samples compared with that in gallbladder mucosa (P < 0.0001), and was associated with multiple clinicopathological factors. Multivariate survival analysis showed that low PGK1 expression was associated with shorter OS (median 12.8 vs 45.4 months; hazard ratio [HR] = 3.077; 95% confidence interval [CI], 1.373-6.897; P = 0.006) and DFS (median 8.3 vs 37.9 months; HR = 2.988; 95% CI, 1.315-6.790; P = 0.009), indicating that PGK1 expression was an independent prognostic factor in patients with GBC.Low PGK1 expression was associated with progression in patients with GBC. PGK1 expression could be a useful prognostic biomarker for GBC.
评估磷酸甘油酸激酶1（PGK1）蛋白表达在胆囊癌（GBC）患者中的预后意义。纳入了2004年1月至2010年12月期间接受GBC手术切除的95例患者。通过10年随访评估总生存期（OS）和无病生存期（DFS）。采用组织芯片和免疫组化评估PGK1表达。使用多因素Cox回归分析预后意义。PGK1在所有胆囊黏膜中均高表达。54.7%（52/95）的GBC患者检测到PGK1表达降低。与胆囊黏膜相比，GBC样本中PGK1表达明显下调（P<0.0001），且与多种临床病理因素相关。多因素生存分析显示，低PGK1表达与较短的OS（中位生存期12.8个月对45.4个月；风险比[HR]=3.077；95%置信区间[CI]，1.373 - 6.897；P=0.006）和DFS（中位生存期8.3个月对37.9个月；HR=2.988；95%CI，1.315 - 6.790；P=0.009）相关，表明PGK1表达是GBC患者的独立预后因素。低PGK1表达与GBC患者病情进展相关。PGK1表达可能是GBC有用的预后生物标志物。
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