Razazian Nazanin, Yavari Zeinab, Farnia Vahid, Azizi Akram, Kordavani Laleh, Bahmani Dena Sadeghi, Holsboer-Trachsler Edith, Brand Serge
1Neurology Department, Kermanshah University of Medical Sciences, Kermanshah, IRAN; 2Substance Abuse Prevention Research Center, Psychiatry Department, Kermanshah University of Medical Sciences, Kermanshah, IRAN; 3Education Department, Kermanshah University of Medical Sciences, Kermanshah, IRAN; 4Kashani Hospital, Isfahan University of Medical Sciences, Isfahan, IRAN; 5Center for Affective, Stress and Sleep Disorders, Psychiatric Clinics of the University of Basel, Basel, SWITZERLAND; 6Department of Sport, Exercise and Health Science, Sport Science Section, University of Basel, Basel, SWITZERLAND.
Med Sci Sports Exerc. 2016 May;48(5):796-803. doi: 10.1249/MSS.0000000000000834.
Multiple sclerosis (MS) is a chronic progressive autoimmune disease impacting both body and mind. Typically, patients with MS report fatigue, depression, and paresthesia. Standard treatment consists of immune modulatory medication, though there is growing evidence that exercising programs have a positive influence on fatigue and psychological symptoms such as depression. We tested the hypothesis that, in addition to the standard immune regulatory medication, either yoga or aquatic exercise can ameliorate both fatigue and depression, and we examined whether these interventions also influence paresthesia compared with a nonexercise control condition.
Fifty-four women with MS (mean age: M = 33.94 yr, SD = 6.92) were randomly assigned to one of the following conditions: yoga, aquatic exercise, or nonexercise control. Their existing immune modulatory therapy remained unchanged. Participants completed questionnaires covering symptoms of fatigue, depression, and paresthesia, both at baseline and on completion of the study 8 wk later.
Compared with the nonexercise control condition and over time, fatigue, depression, and paresthesia decreased significantly in the yoga and aquatic exercise groups. On study completion, the likelihood of reporting moderate to severe depression was 35-fold higher in the nonexercise control condition than in the intervention conditions (yoga and aquatic exercising values collapsed).
The pattern of results suggests that for females with MS and treated with standard immune regulatory medication, exercise training programs such as yoga and aquatic exercising positively impact on core symptoms of MS, namely, fatigue, depression, and paresthesia. Exercise training programs should be considered in the future as possible complements to standard treatments.
多发性硬化症（MS）是一种影响身心的慢性进行性自身免疫性疾病。通常，MS患者会出现疲劳、抑郁和感觉异常。标准治疗包括免疫调节药物，不过越来越多的证据表明，运动项目对疲劳和抑郁等心理症状有积极影响。我们检验了这样一个假设：除标准免疫调节药物外，瑜伽或水上运动都可以改善疲劳和抑郁，并且我们研究了与非运动对照条件相比，这些干预措施是否也会影响感觉异常。
54名患有MS的女性（平均年龄：M = 33.94岁，标准差 = 6.92）被随机分配到以下条件之一：瑜伽、水上运动或非运动对照。她们现有的免疫调节治疗保持不变。参与者在基线时以及8周后研究结束时完成了涵盖疲劳、抑郁和感觉异常症状的问卷。
与非运动对照条件相比，且随着时间推移，瑜伽组和水上运动组的疲劳、抑郁和感觉异常显著减轻。在研究结束时，非运动对照条件下报告中度至重度抑郁的可能性比干预条件（瑜伽和水上运动的值合并计算）高35倍。
结果模式表明，对于接受标准免疫调节药物治疗的MS女性患者，瑜伽和水上运动等运动训练项目对MS的核心症状，即疲劳、抑郁和感觉异常有积极影响。未来应考虑将运动训练项目作为标准治疗的可能补充。
