University of Basel, Psychiatric Clinics (UPK), Center of Affective, Stress and Sleep Disorders (ZASS), Basel, Switzerland; Kermanshah University of Medical Sciences (KUMS), Substance Abuse Prevention Research Center, Health Institute, and Sleep Disorders Research Center, Kermanshah, Iran; Isfahan Neurosciences Research Center, Alzahra Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran.
Kermanshah University of Medical Sciences, Neurology Department, Kermanshah, Iran.
Mult Scler Relat Disord. 2019 Nov;36:101356. doi: 10.1016/j.msard.2019.07.032. Epub 2019 Jul 29.
In persons with multiple sclerosis (MS), physical activity favorably impacts on psychological well-being. The aims of the present study were to investigate the influence of physical activity on depression, fatigue, sleep, paresthesia, and personality traits (intolerance of uncertainty), and to explore, if endurance training or coordinative training are superior to an active control condition.
92 female individuals with MS (mean age: 37.36 years; mean EDSS: 2.43) took part in this intervention study. Participants were randomly assigned either to endurance training, coordinative training, or to an active control condition. At baseline, 4 weeks, and 8 weeks later at the end of the study, participants completed questionnaires on sleep, depression, fatigue, paresthesia and intolerance of uncertainty. Exercise training interventions took place three times/week for 45 min/session. Participants in the active control condition also met with the same duration and frequency.
Sleep complaints and symptoms of depression decreased over time, but more so in the exercising groups, compared to the active control group. No changes over time and between groups were observed for fatigue, paresthesia, and intolerance of uncertainty.
Both endurance and coordinative exercising had the potential to favorably impact on some aspects of cognitive-emotional processing, while also an active control condition appeared to have a positive impact.
在多发性硬化症（MS）患者中，身体活动对心理健康有积极影响。本研究的目的是调查身体活动对抑郁、疲劳、睡眠、感觉异常和人格特质（不确定性容忍度）的影响，并探讨耐力训练或协调训练是否优于积极对照组。
92 名女性多发性硬化症患者（平均年龄：37.36 岁；平均 EDSS：2.43）参加了这项干预研究。参与者被随机分配到耐力训练组、协调训练组或积极对照组。在基线、4 周和 8 周后研究结束时，参与者完成了关于睡眠、抑郁、疲劳、感觉异常和不确定性容忍度的问卷。运动训练干预每周进行 3 次，每次 45 分钟/次。积极对照组的参与者也以相同的时间和频率进行会面。
随着时间的推移，睡眠问题和抑郁症状有所减轻，但锻炼组比积极对照组减轻得更明显。疲劳、感觉异常和不确定性容忍度没有随时间和组间变化。
耐力和协调运动都有可能对认知情感处理的某些方面产生积极影响，而积极对照组似乎也有积极影响。
